SERS ultrasensitive universal sensing of proteins through cross-reactive sensor arrays

Projektinformationen

Cross-SERS

ID Finanzhilfevereinbarung: 329131

Abgeschlossenes Projekt

Startdatum 1 Mai 2013

Enddatum 30 April 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 166 336,20

EU-Beitrag € 166 336,20

Koordiniert durch

UNIVERSITAT ROVIRA I VIRGILI
Spain

Ziel

The goal of the present project is the development of novel nanostructured cross-sensor reactive arrays (CRSA) based on SERS and the different affinity of peptides and proteins to interact with different metallorganic complexes. This sensor concept will be universal for the ultrasensitive detection and identification of metallic cations and peptides/proteins. Briefly, we shall fabricate micron-sized, composite nanomaterials as follows. Gold nanoparticles will be first deposited on silica or polymer microspheres via layer by layer self-assembly, and subsequent epitaxial growth will be carried out with silver (using novel methods recently developed in our lab) to generate discrete, highly SERS active surfaces. These composite particles will be functionalized with organic ligands with high affinity for metals (thiolated porphyrins and terpyridines). In a first step, quantitative multiplex ultrasensitive detection of metals will be aimed. In a second step, each microsphere coupled with one ligand and a given metal will be fabricated as a sensing element for the CRSA. These sensing elements will be organized into solid supports (the actual CRSA) and tested for the identification of different protein species, especially those related with pathogenic states or drug abuse, by combining SERS spectroscopy with chemometric methods (i.e. principal component analysis, hierarchical cluster analysis and partial least squares). The final product is intended to be mounted on a conventional glass slide with ability for drawing a rapid and accurate conclusion on the health condition of a patient, or environmental risk in a time scale of seconds.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › chemical sciences › polymer sciences
• medical and health sciences › health sciences › substance abuse
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• natural sciences › physical sciences › optics › spectroscopy

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITAT ROVIRA I VIRGILI

Kontakt Verwaltung

Ramon A. Alvarez-Puebla (Prof.)

• EU-Beitrag: € 166 336,20
• Adresse: CARRER DE ESCORXADOR ; 43003 Tarragona ; Spanien
• Region: Este › Cataluña › Tarragona
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten