Objectif The ERC starting grant CellControl awarded to the Principal Investigator Yaakov Benenson funds research directed toward rational design and construction of gene circuits and networks for programmable control of cell physiology. One of the potential applications of this research is in the development of next-generation anticancer treatments that incorporate recently acquired knowledge on the complexity of cancer-related regulatory pathways, tumor development and differentiation, and the rise of cancer clones resistant to standard therapies. These new treatments are necessarily more complex than small molecule drugs, yet they are within reach of latest tools developed in gene therapy and they hold the promise of much higher efficacy and lower toxicity as well as robustness to the emergence of resistant clones. Thus our approach could be of great potential for treating metastatic and primary malignant tumors.We have already shown an engineered circuit that selectively detects and eliminates specific cancer cells in vitro. Powered by additional developments in the framework of the ERC starting grant, we have designed an even safer and more selective circuit that can serve as a starting point for pre-clinical and eventually clinical testing. In this proposal we describe proof-of-concept experiments that will show feasibility of our approach in a mouse model. Successful demonstration will pave the way to large-scale translational R&D financed by private investors, and eventually to the deployment of these new therapies in the clinic. Champ scientifique medical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-OA-2012-PoC - European Research Council ERC Proof of Concept Appel à propositions ERC-2012-PoC Voir d’autres projets de cet appel Régime de financement CSA-SA(POC) - Supporting action (Proof of Concept) Institution d’accueil EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Contribution de l’UE € 149 499,00 Adresse Raemistrasse 101 8092 Zuerich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Contact administratif Yaakov Benenson (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Suisse Contribution de l’UE € 149 499,00 Adresse Raemistrasse 101 8092 Zuerich Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Contact administratif Yaakov Benenson (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée