Objective
The ability of cells to move invasively through the cellular junctions of the endothelial vasculature underlies the function of the immune system and the metastatic spread of cancer. How the invading and the invaded cells communicate to synchronize their actions during this behavior remains unclear. We are studying these questions using the developmental migration of Drosophila immune cells through an epithelial barrier. We have identified many mutants required for this process in a preliminary screen and are particularly intrigued by 5 transporter genes. These are excellent candidates to be transmitting coordinating signals between the immune cells and the epithelia and will be the focus of this proposal. We seek to determine which of these transporters are specific for invasive migration and could act at the cell surface to facilitate signal transmission; we will pick one which fits this criterion and create a null allele of it. We will then investigate what process this transporter affects. We have shown previously that invasion requires changes in adherens junctions and integrin affinity through the relocalization of an integrin modulator Rap1. We will examine our chosen mutant in these assays, and develop new ones to assess volume changes and chain migration if needed. Then we will determine if the role in junctional penetration that we identify for this gene in Drosophila is also conserved in vertebrate immune cells. Thus our work will identify a new component for invasion, the process it plays a role in and its relevance for important vertebrate physiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
3400 KLOSTERNEUBURG
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.