Objective
The motivations for studying the gaseous structures of peptides and proteins range from developing efficient methodologies for protein identification and quantification to fundamental understanding of folding processes and biomolecular architectures. Mass spectrometry allows analyzing biomolecular ions in a variety of different forms, for example, as a function of charge state, bound to their targets or in multimers following aggregation. Ion mobility-mass spectrometry is a revolutionary technique regarding the separation of complex mixtures and structural isomers and can now play an important role in the study of protein shapes and their complexes. In parallel, optical spectroscopy is also emerging as a key element in gas phase methods available for investigating biomolecular ions. In this proposal, we want to combine spectroscopic approaches with high resolution mass spectrometry and ion mobility to widen and deepen the scope of mass spectrometry in its various fields of applications including structural biology, protein identification and quantification. The general idea behind our approach is to simultaneously obtain “orthogonal” information on gas phase molecular conformation from ion mobility and optical spectroscopy, with in addition the possibility of using light to induce conformational changes or the formation of new species. A goal of this cross-disciplinary proposal is to study the structural reorganization of proteins occurring in relation to aggregation, radical formation and oxidation, focusing on misfolding and the earliest stages of tau protein assembly. Moreover, fundamental understanding of structure and reactivity of peptides and proteins will serve as a lever for the development of applications in analytical sciences using photon based dissociation. Major advances are expected from pioneering instrument development and from crossing boundaries between physics, chemistry and biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences molecular biology structural biology
- natural sciences physical sciences theoretical physics particle physics photons
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-ADG_20120216
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.