Objective
Personalized cancer vaccines are therapeutic vaccines custom tailored to target tumor-specific mutations unique to a given patient. Such a treatment offers great hope for cancer patients as it does not harm healthy cells and has the potential to provide life-long remission. The emerging view of cancer as a dynamic evolutionary process that produces startling genetic heterogeneity and escapes treatment poses challenges for cancer vaccines. Yet progress in elucidating the nature of tumor heterogeneity has been impeded by experimental challenges, and the impact on vaccine design has not been investigated. The comprehensive research agenda outlined in this proposal aims to investigate tumor heterogeneity at the single cell level using novel experimental and theoretical methods with the end goal of maximizing the efficacy of personalized cancer vaccines. To accomplish these goals, I will first develop cost-effective high-throughput methods to measure the “mutanome” of hundreds of single cancer cells, integrating next-generation sequencing with microfluidics. Next, novel lineage treeing algorithms will be developed to reconstruct the evolutionary history of the cancer. I will then systematically apply this method to murine and human tumors and thus shed new light on cancer heterogeneity and evolution, reveal driver mutations with unprecedented resolution, enable the design of highly potent cancer vaccines and pave the way for new diagnostic tools. This proposal fits well within the scope of research conducted by the host institute, which aims to develop fundamentally new individualized cancer immunotherapies, with the first personalized cancer vaccines entering clinical trials in the near future. The host institute therefore has the experience and the resources to support this proposal and maximize its translational impact.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences evolutionary biology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
55131 Mainz
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.