Objective
Patients with brain tumours have limited treatment options and could benefit from new treatments. Focused ultrasound (FUS) combined with a microbubble agent, under guidance of magnetic resonance (MR) imaging, has been used in animal studies to temporarily open the blood-brain-barrier (BBB). The BBB normally protects the brain by blocking most substances from the blood and is a hurdle to the use of therapeutic agents in the brain. The ability to use FUS induced BBB disruption to target drugs to desired volumes in the brain presents a potentially huge advance for neuroscience. The method can also increase the permeability of the blood-tumour barrier, which often retains many characteristics of the normal BBB. To translate this technique to clinical applications, the effectiveness of the technique should be demonstrated. Patients with no or limited treatment options are probably the most willing candidates to participate in a clinical trial, e.g. breast cancer patients with brain metastases. For extracranial metastases in breast cancer patients two antibody agents have shown good results. Their effectiveness in brain metastases is limited, due to the BBB. Permeabilization of the BBB might improve survival in this group of patients. Animal studies with these drugs will be performed to study the survival and tumour progression in rats. The rats will be divided in different treatment groups, animals that 1) get one or both drugs combined with FUS induced BBB permeabilization; 2) only get one or both drugs; 3) only receive FUS induced BBB permeabilization; and 4) receive no treatment. The results of this project will guide future clinical studies. MRguided FUS for targeted drug delivery in the brain is a new and revolutionary technique, with possibilities in many diseases of the central nervous system. As there is limited research in Europe involving this technique, it is important for the ERA to increase the knowledge in Europe and expand research on this topic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.