Objetivo Protein kinases are involved in the control of a large number of cellular processes and play a central role in human physiology. More than 500 genes encoding protein kinases have been identified in the human genome, and it is estimated that about 30% of all human proteins may be phosphorylated by kinases. Deficiency in kinase activity has implications in cancer, central nervous system disorders, autoimmune diseases and immunosuppression, diabetes, osteoporosis and various metabolic disorders. Small-molecule kinase inhibitors have therefore moved into the focus of the pharmaceutical industry as a new class of drugs, which is expected to produce new and more efficient treatments and grow significantly within the coming decade.The proposed project brings together the unique and proprietary technologies of three SMEs and the expertise of academic research partners to create a new platform for lead compound discovery with a focus on protein kinases. Three kinases will be targeted for the development of inhibitory compounds. The academic partners will contribute a modern high throughput platform for protein expression and crystallisation (Israel Structural Proteomics Centre), and expertise in the biochemistry and biology of the targeted kinases combined with the principles of the use of bioisosterism in synthesis of novel chemical compounds (University of Turin). The applied principles and technologies will provide new IP opportunities for the partner SMEs in the otherwise crowded kinase inhibitor IP space and will help in the design of new strategies in the discovery of inhibitors for novel kinase targets in the treatment of cancer. The generated compounds will be sold and/or out-licensed to large pharmaceutical companies for continued development. This market is currently undergoing continuous expansion due to large cuts in early drug discovery within most pharmaceutical companies. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncology Programa(s) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Tema(s) SME-2012-1 - Research for SMEs Convocatoria de propuestas FP7-SME-2012 Consulte otros proyectos de esta convocatoria Régimen de financiación BSG-SME - Research for SMEs Coordinador SAROMICS BIOSTRUCTURES AB Aportación de la UE € 407 700,00 Dirección MEDICON VILLAGE 223 81 Lund Suecia Ver en el mapa Región Södra Sverige Sydsverige Skåne län Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Salam Al-Karadaghi (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo PRESTWICK CHEMICAL SAS Francia Aportación de la UE € 382 831,00 Dirección BOULEVARD GONTHIER D'ANDERNACH 67400 ILLKIRCH-GRAFFENSTADEN Ver en el mapa Región Grand Est Alsace Bas-Rhin Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Paul Bikard (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos KTB TUMORFORSCHUNGSGESELLSCHAFT MBH Alemania Aportación de la UE € 358 466,00 Dirección BREISACHER STRASSE 117 79106 FREIBURG Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Michael Kubbbutat (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos UNIVERSITA DEGLI STUDI DI TORINO Italia Aportación de la UE Sin datos Dirección VIA GIUSEPPE VERDI 8 10124 Torino Ver en el mapa Región Nord-Ovest Piemonte Torino Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Marco Piccinini (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Francia Aportación de la UE Sin datos Dirección RUE MICHEL ANGE 3 75794 Paris Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Gaelle Bujan (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos WEIZMANN INSTITUTE OF SCIENCE Israel Aportación de la UE Sin datos Dirección HERZL STREET 234 7610001 Rehovot Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Talia Tzahor (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos