Objective
Although oligoprolines have been known for decades up till the recent years they have only been applied as spacers in the study of energy and electron transfer phenomena. Recently a new methodology for the functionalisation of their backbones has been developed. The great flexibility of the reported synthetic approach both with respect to the number and character of introduced motifs allows for effective fine-tuning of the properties of these helical oligopeptides.
Herein we propose to apply functionalised oligoprolines as novel asymmetric organocatalysts and chiral ligands for metal-catalysed transformations. Successful demonstration that the helical chirality can be transferred efficiently into an enantioselective transformation will be a very important contribution to the area and may result in the establishment of new class of catalysts.
We also aim at creating switchable systems in which we will control the catalytic activity of these compounds by a simple, external stimuli. This will constitute a major achievement in the fast growing area of modern chemical sciences focusing on mimicking the behaviour of natural catalytic systems.
The ultimate goal of the project however is design and operation of a supramolecular catalytic assembly line consisting of oligoproline units. We plan to create a platform which will catalyse the synthesis of an oligomeric specie from monomers in solution, however only when its’ single oligoproline components assemble together to create the ‘active form’ of the catalytic system. Successful accomplishment of this task will be a landmark contribution to the fields enantioselective catalysis, supramolecular chemistry and nanotechnology and could lay the foundations for a new class of functional synthetic systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.