Objective
The aim of this research proposal is to employ microreactor technology in order to boost the palladium(II)-catalyzed C–H carbonylation reaction. In this way, the approach described in this proposal is conceptually different from the traditional batch strategies, which are currently published in the scientific literature. The ability to use elevated temperatures in a safe and reliable way may assist the deprotonation step, which is required to enable C–H functionalization. In addition, excellent interfacial contact between gaseous CO and the liquid phase can be expected in micro flow. This feature of microreactor technology allows for an enhancement of the mass-transfer from the gas to the liquid phase. Different flow regimes will be evaluated during this project in order to facilitate CO transfer. In addition, increasing the CO gas pressure leads to a further increase of the concentration of gaseous components in the liquid phase. Such reaction conditions need specialized equipment in batch processes, such as Parr bombs or autoclaves, but can be easily achieved in micro flow through combination of back pressure regulators and high pressure pumps. Consequently, by employing elevated temperatures and pressures, the applicant foresees that C–H carbonylation reactions can be accelerated significantly.
Key objectives in this research proposal:
1. Development of a microfluidic setup for the C–H carbonylation chemistry.
2. Providing a comprehensive study on the influence of temperature and pressure on the C–H carbonylation reaction.
3. Investigating the influence of the flow regime on the C–H carbonylation reaction.
4. Exploiting the insights gained in objectives 1-3, the applicant expects to understand the key factors affecting the reactivity of the C–H carbonylation systems and this will allow us to broaden the reaction scope, leading to a myriad of novel compounds relevant for drug discovery and material science.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences chemical sciences inorganic chemistry transition metals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.