Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

FP7 Breast modelling

VPH-PRISM

Project ID: 601040
Financé au titre de

Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling

De 2013-03-01 à 2016-02-29, projet clôturé | VPH-PRISM Site web

Détails concernant le projet

Coût total:

EUR 5 167 657

Contribution de l'UE:

EUR 3 720 000

Coordonné à/au(x)/en:

Austria

Appel à propositions:

FP7-ICT-2011-9See other projects for this call

Régime de financement:

CP - Collaborative project (generic)

Description

Personalised predictive modelling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments.

VPH-PRISM (Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy through Integrated Tissue Micro-Structure Modeling) addresses these key topics with integrated multidisciplinary, multi-scale ICT modelling of breast tissue microstructure in the context of environmental, genetic, and clinical factors.

VPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at both early and advanced stages of breast cancer.

The EU funded project consists of 9 project partners with leading expertise in the field of pathological and radiological imaging, image processing as well as biophysical and statistical modelling, with EIBIR as the coordinating partner. The 3-year project offical start date is 1 March 2013 and is supported by the European Commission with a financial contribution of €3.7m.

Objectif

Breast cancer is frequent and life threatening, but curable if detected early. Early detection and comprehensive characterisation of findings require optimized imaging and image understanding to maximise detection of significant disease while preventing overdiagnosis. Personalised predictive modeling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM addresses these key topics with integrated multidisciplinary, multi-scale ICT modeling of breast tissue microstructure in the context of environmental, genetic, and clinical factors.
Key challenges include establishment of combined biomarkers from the automated analysis and spatial correlation of digital pathology and advanced breast imaging. Tissue characterisation includes the peritumoral stroma, a key in tumour progression and therapy response. Comprehensive clinical breast cancer phenotypes are extracted from prospectively collected multidisciplinary data. Interactions of environmental and genetic factors with specific breast tissue patterns are analysed in three large ongoing population-based imaging cohorts. A standard breast model enables efficient, combined statistical modeling of sparsely sampled and heterogeneous, large-scale data across disciplines, scales, structures, time and patients.
Using the developed tools and models, and the data collected, we will:• improve estimates of tumour spread to aid surgery and assess chemo- and radiotherapeutic response• optimise multi-modal imaging methods through biophysical forward modeling of image formation for more efficient phenotyping and imaging biomarkers• predict personal risks for cancer progression and select optimal treatment strategies
VPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at early and advanced stages of breast cancer.

Coordinateur

EIBIR GEMEINNUETZIGE GMBH ZUR FOERDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria

Contribution de l'UE: EUR 247 120


Neutorgasse 9/2
1010 VIENNA
Austria
Activity type: Research Organisations
Contact administratif: Pamela Zolda
Tél.: +4315334064 538
E-mail

Participants

Medizinische Universitaet Wien
Austria

Contribution de l'UE: EUR 199 992


Spitalgasse
A-1090 Vienna
Austria
Activity type: Higher or Secondary Education Establishments
Contact administratif: Christian Herold
Tél.: +43 1 404004818
E-mail
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany

Contribution de l'UE: EUR 888 761


HANSASTRASSE 27C
80686 MUNCHEN
Germany
Activity type: Research Organisations
Contact administratif: Christoph Schulte
Tél.: +49 89 1205 2728
Fax: +49 89 1205 7534
E-mail
PHILIPS TECHNOLOGIE GMBH
Fin de participation
Germany

Contribution de l'UE: EUR 509 262


LUEBECKERTORDAM 5
20099 HAMBURG
Germany
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif: Patrick Keur
Tél.: +31 402740361
Fax: +31 40 2744797
E-mail
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands

Contribution de l'UE: EUR 709 780


GEERT GROOTEPLEIN NOORD 9
6525 EZ NIJMEGEN
Netherlands
Activity type: Higher or Secondary Education Establishments
Contact administratif: Maarten van Langen
Tél.: +31 243618937
E-mail
UNIVERSITY COLLEGE LONDON
United Kingdom

Contribution de l'UE: EUR 539 868


GOWER STREET
WC1E 6BT LONDON
United Kingdom
Activity type: Higher or Secondary Education Establishments
Contact administratif: Mark Burgess
Tél.: +44 2076791768
E-mail
UNIVERSITY OF DUNDEE
United Kingdom

Contribution de l'UE: EUR 255 917


Nethergate
DD1 4HN DUNDEE
United Kingdom
Activity type: Higher or Secondary Education Establishments
Contact administratif: Zoe Kidd
Tél.: +441382384047
E-mail
BOCA RATON REGIONAL HOSPITAL INC NON PROFIT CORPORATION
United States

Contribution de l'UE: EUR 84 000


MEADOWS ROAD
33486 BOCA RATON, FLORIDA
United States
Activity type: Research Organisations
Contact administratif: Viviana Boronat
Tél.: +15619554800
E-mail
THE UNIVERSITY OF CHICAGO
United States

Contribution de l'UE: EUR 285 300


S ELLIS AVE 5801
60637 Chicago
United States
Activity type: Higher or Secondary Education Establishments
Contact administratif: John Philipps
Tél.: +773 7028203
Fax: +773 7022142
E-mail