Opis projektu Virtual Physiological HumanPersonalised predictive modelling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM (Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy through Integrated Tissue Micro-Structure Modeling) addresses these key topics with integrated multidisciplinary, multi-scale ICT modelling of breast tissue microstructure in the context of environmental, genetic, and clinical factors. VPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at both early and advanced stages of breast cancer. The EU funded project consists of 9 project partners with leading expertise in the field of pathological and radiological imaging, image processing as well as biophysical and statistical modelling, with EIBIR as the coordinating partner. The 3-year project offical start date is 1 March 2013 and is supported by the European Commission with a financial contribution of €3.7m. Pokaż cel projektu Ukryj cel projektu Breast cancer is frequent and life threatening, but curable if detected early. Early detection and comprehensive characterisation of findings require optimized imaging and image understanding to maximise detection of significant disease while preventing overdiagnosis. Personalised predictive modeling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM addresses these key topics with integrated multidisciplinary, multi-scale ICT modeling of breast tissue microstructure in the context of environmental, genetic, and clinical factors.Key challenges include establishment of combined biomarkers from the automated analysis and spatial correlation of digital pathology and advanced breast imaging. Tissue characterisation includes the peritumoral stroma, a key in tumour progression and therapy response. Comprehensive clinical breast cancer phenotypes are extracted from prospectively collected multidisciplinary data. Interactions of environmental and genetic factors with specific breast tissue patterns are analysed in three large ongoing population-based imaging cohorts. A standard breast model enables efficient, combined statistical modeling of sparsely sampled and heterogeneous, large-scale data across disciplines, scales, structures, time and patients.Using the developed tools and models, and the data collected, we will: improve estimates of tumour spread to aid surgery and assess chemo- and radiotherapeutic response optimise multi-modal imaging methods through biophysical forward modeling of image formation for more efficient phenotyping and imaging biomarkers predict personal risks for cancer progression and select optimal treatment strategiesVPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at early and advanced stages of breast cancer. Dziedzina nauki medical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesbasic medicinepathology Program(-y) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Temat(-y) ICT-2011.5.2 - Virtual Physiological Human Zaproszenie do składania wniosków FP7-ICT-2011-9 Zobacz inne projekty w ramach tego zaproszenia System finansowania CP - Collaborative project (generic) Koordynator EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Wkład UE € 247 120,00 Adres Am gestade 1 1010 Wien Austria Zobacz na mapie Region Ostösterreich Wien Wien Rodzaj działalności Research Organisations Kontakt administracyjny Pamela Zolda (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MEDIZINISCHE UNIVERSITAET WIEN Austria Wkład UE € 199 992,00 Adres Spitalgasse 23 1090 Wien Zobacz na mapie Region Ostösterreich Wien Wien Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Christian Herold (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Niemcy Wkład UE € 888 761,00 Adres Hansastrasse 27c 80686 Munchen Zobacz na mapie Region Bayern Oberbayern München, Kreisfreie Stadt Rodzaj działalności Research Organisations Kontakt administracyjny Christoph Schulte (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych PHILIPS TECHNOLOGIE GMBH Zakończenie uczestnictwa Niemcy Wkład UE € 509 262,00 Adres Luebeckertordamm 5 20099 Hamburg Zobacz na mapie Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Patrick Keur (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych STICHTING RADBOUD UNIVERSITEIT Niderlandy Wkład UE € 709 780,00 Adres Houtlaan 4 6525 XZ Nijmegen Zobacz na mapie Region Oost-Nederland Gelderland Arnhem/Nijmegen Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Maarten van Langen (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY COLLEGE LONDON Wkład UE € 539 868,00 Adres Gower street WC1E 6BT London Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Mark Burgess (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF DUNDEE Zjednoczone Królestwo Wkład UE € 255 917,00 Adres Nethergate DD1 4HN Dundee Zobacz na mapie Region Scotland Eastern Scotland Angus and Dundee City Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Zoe Kidd (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych BOCA RATON REGIONAL HOSPITAL INC NON PROFIT CORPORATION Stany Zjednoczone Wkład UE € 84 000,00 Adres Meadows road 33486 Boca raton, florida Zobacz na mapie Rodzaj działalności Research Organisations Kontakt administracyjny Viviana Boronat (Ms.) Linki Kontakt z organizacją Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF CHICAGO Stany Zjednoczone Wkład UE € 285 300,00 Adres S ellis ave 5801 room 503 60637 Chicago illinois Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny John Philipps (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych