Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

FP7 Breast modelling

VPH-PRISM

Project ID: 601040
Źródło dofinansowania

Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling

Od 2013-03-01 do 2016-02-29, projekt zakończony | VPH-PRISM Witryna

Dane projektu

Całkowity koszt:

EUR 5 167 657

Wkład UE:

EUR 3 720 000

Kraj koordynujący:

Austria

Zaproszenie do składania wniosków:

FP7-ICT-2011-9See other projects for this call

System finansowania:

CP - Collaborative project (generic)

Description

Personalised predictive modelling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments.

VPH-PRISM (Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy through Integrated Tissue Micro-Structure Modeling) addresses these key topics with integrated multidisciplinary, multi-scale ICT modelling of breast tissue microstructure in the context of environmental, genetic, and clinical factors.

VPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at both early and advanced stages of breast cancer.

The EU funded project consists of 9 project partners with leading expertise in the field of pathological and radiological imaging, image processing as well as biophysical and statistical modelling, with EIBIR as the coordinating partner. The 3-year project offical start date is 1 March 2013 and is supported by the European Commission with a financial contribution of €3.7m.

Cel

Breast cancer is frequent and life threatening, but curable if detected early. Early detection and comprehensive characterisation of findings require optimized imaging and image understanding to maximise detection of significant disease while preventing overdiagnosis. Personalised predictive modeling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM addresses these key topics with integrated multidisciplinary, multi-scale ICT modeling of breast tissue microstructure in the context of environmental, genetic, and clinical factors.
Key challenges include establishment of combined biomarkers from the automated analysis and spatial correlation of digital pathology and advanced breast imaging. Tissue characterisation includes the peritumoral stroma, a key in tumour progression and therapy response. Comprehensive clinical breast cancer phenotypes are extracted from prospectively collected multidisciplinary data. Interactions of environmental and genetic factors with specific breast tissue patterns are analysed in three large ongoing population-based imaging cohorts. A standard breast model enables efficient, combined statistical modeling of sparsely sampled and heterogeneous, large-scale data across disciplines, scales, structures, time and patients.
Using the developed tools and models, and the data collected, we will:• improve estimates of tumour spread to aid surgery and assess chemo- and radiotherapeutic response• optimise multi-modal imaging methods through biophysical forward modeling of image formation for more efficient phenotyping and imaging biomarkers• predict personal risks for cancer progression and select optimal treatment strategies
VPH-PRISM will provide a proof of concept for multidisciplinary model based discovery of environment-tissue interactions, quantitative drug efficacy assessment, surgery planning, and treatment outcome prediction at early and advanced stages of breast cancer.

Koordynator

EIBIR GEMEINNUETZIGE GMBH ZUR FOERDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria

Wkład UE: EUR 247 120


Neutorgasse 9/2
1010 VIENNA
Austria
Activity type: Research Organisations
Kontakt administracyjny: Pamela Zolda
Tel.: +4315334064 538

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Uczestnicy

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Wkład UE: EUR 199 992


SPITALGASSE 23
1090 WIEN
Austria
Activity type: Higher or Secondary Education Establishments
Kontakt administracyjny: Christian Herold
Tel.: +43 1 404004818

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FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Germany

Wkład UE: EUR 888 761


HANSASTRASSE 27C
80686 MUNCHEN
Germany
Activity type: Research Organisations
Kontakt administracyjny: Christoph Schulte
Tel.: +49 89 1205 2728
Faks: +49 89 1205 7534

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PHILIPS TECHNOLOGIE GMBH
Uczestnictwo zakończone
Germany

Wkład UE: EUR 509 262


LUEBECKERTORDAMM 5
20099 HAMBURG
Germany
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny: Patrick Keur
Tel.: +31 402740361
Faks: +31 40 2744797

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Stichting Katholieke Universiteit / Radboud university medical center
Netherlands

Wkład UE: EUR 709 780


Geert Grooteplein Noord
6525 EZ Nijmegen
Netherlands
Activity type: Higher or Secondary Education Establishments
Kontakt administracyjny: Maarten van Langen
Tel.: +31 243618937

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UNIVERSITY COLLEGE LONDON
United Kingdom

Wkład UE: EUR 539 868


GOWER STREET
WC1E 6BT LONDON
United Kingdom
Activity type: Higher or Secondary Education Establishments
Kontakt administracyjny: Mark Burgess
Tel.: +44 2076791768

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University of Dundee
United Kingdom

Wkład UE: EUR 255 917


Nethergate
DD1 4HN Dundee
United Kingdom
Activity type: Higher or Secondary Education Establishments
Kontakt administracyjny: Zoe Kidd
Tel.: +441382384047

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BOCA RATON REGIONAL HOSPITAL INC NON PROFIT CORPORATION
United States

Wkład UE: EUR 84 000


MEADOWS ROAD
33486 BOCA RATON, FLORIDA
United States
Activity type: Research Organisations
Kontakt administracyjny: Viviana Boronat
Tel.: +15619554800

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THE UNIVERSITY OF CHICAGO
United States

Wkład UE: EUR 285 300


S ELLIS AVE 5801
60637 Chicago
United States
Activity type: Higher or Secondary Education Establishments
Kontakt administracyjny: John Philipps
Tel.: +773 7028203
Faks: +773 7022142

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