Cel "Traditionally, cancer researchers have focused their best efforts on studying the genetic alterations affecting the coding genes. Subsequently, it was observed that in addition to genetic alterations, epigenetic alterations affecting coding genes play an important role in tumor development. In the last decade, largely due to the ability to sequence the human genome and the observation that much of the genome is transcribed but not translated, genes known as ""non-coding RNAs"" (ncRNAs) have attracted great interest in relation to their biological functions and their role in human tumors. In addition to the small ncRNAs like miRNAs, is also revealing that the human genome also encodes numerous long non-coding RNAs (lncRNAs). Some of these lncRNAs are being found in the intergenic regions of the genome (long intergenic non-coding RNAs - lincRNAs). It is estimated that there may be more than 8000 lincRNAs in the human genome. The mechanism that regulates these lincRNAs and the functional mechanism of the vast majority of these lincRNAs are not known, but the few that have been studied are known to exert their function in the nucleus and to be involved in chromatin remodeling and transcription regulation. The expression of lincRNAs is altered in cancer, playing an important role in the initiation, prognosis and progression of human neoplasies. In this regard, preliminary results from our group show that DNA methylation may play an important role in the regulation of lincRNAs and probably in the pathogenesis of hematological malignancies.For all these reasons, the objectives of this “LincMHeM” proposal are to determine whether inappropriate DNA methylation is involved in regulating lincRNA expression, and if such deregulated lincRNAs are involved in pathogenesis and are potential therapeutic targets for treating B cell hematological malignancies (multiple myeloma, lymphoma and acute lymphoblastic leukemia)." Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesclinical medicineoncologyleukemianatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2012-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2012-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Wkład UE € 352 823,70 Adres AVENIDA DE PIO XII 55 31008 Pamplona Hiszpania Zobacz na mapie Region Noreste Comunidad Foral de Navarra Navarra Rodzaj działalności Research Organisations Kontakt administracyjny Ana Iglesias Garcia (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych