Objective
"An important factor that influences therapy response and prognosis of cancer patients has been identified as intratumoral heterogeneity. Gastrointestinal cancers are known to be morphologically and molecularly very heterogeneous diseases. Thus, there is a strong need to identify clinically relevant tumor subpopulations and characterize their genetic and proteomic features. A novel technology which allows the untargeted and spatially resolved analysis of the molecular content of tissues while preserving the histology of the tissue sections is MALDI (matrix-assisted laser desorption/ionization) imaging mass spectrometry, in short MALDI imaging. It has been demonstrated that MALDI imaging constitutes a unique tool to discover tumor subpopulations based solely on the detected mass spectrometry profiles that are not distinguishable by conventional histopathological methods. The objectives of this project are (i) to identify clinical relevant tumor subpopulations by MALDI imaging in gastrointestinal cancers with regard to disease outcome and metastasis as clinical endpoints, and (ii) to characterize the molecular properties of these subpopulations on a genetic, proteomic, and metabolomic level. This could provide more knowledge about the biology of tumors and their molecular variance, and result in novel markers for therapy prediction or prognosis of patients, thus aiding the progress towards more personalized-medicine."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences histology
- natural sciences physical sciences optics laser physics
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2333 ZA Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.