Molecular Targets of Uranium in some Aquatic Organisms

Projektinformationen

MOTAUR

ID Finanzhilfevereinbarung: 329969

Abgeschlossenes Projekt

Startdatum 2 Januar 2014

Enddatum 1 Januar 2016

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 202 405,80

EU-Beitrag € 202 405,80

Koordiniert durch

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Ziel

Uranium is an important element, massively used in military and civil industry. It is a toxic element and the understanding of the mechanisms of its metabolism, homeostasis and toxicity are of paramount importance. The project aims at the development of a series of novel analytical methods able to identify and quantify the species being products of interaction of uranium with the proteome and metabolome of some aquatic organisms. The organisms include microalgae Fragilariopsis cylindrus and Karenia brevis selected on the basis of reports claiming their unusual toxic metal homeostasis, some shellfish crayfish Orconectes limosus, bivalve Corbicula fluminea known for uranium bioaccumulation, and a model organism zebrafish Danio reiro. The methods to be developed to probe biomolecular targets of uranium include non-denaturating gel electrophoresis with uranium specific laser ablation ICP mass spectrometry imaging followed by canonical proteomics protocols and hydrophilic interaction chromatography with the high-resolution MS detection of uranium complexes present. The maps of the interactions of uranium with biomolecules will be discussed in the context of toxicological data.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › chemical sciences › electrochemistry › electrophoresis
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry
• medical and health sciences › basic medicine › physiology › homeostasis
• natural sciences › physical sciences › optics › laser physics

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Kontakt Verwaltung

Gaelle Bujan (Ms.)

• EU-Beitrag: € 202 405,80
• Adresse: RUE MICHEL ANGE 3 ; 75794 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten