Objective
In a world with increasing population and limited resources, the development of new synthetic procedures will not only be judged by their yield and/or product selectivity, but also by their ecological and economical footprint. Mechanochemistry is a branch of sustainable chemistry which involves a rapid and clean way to transfer the energy needed for the chemical transformation, using friction, via either ball-milling or grinding. In this project, we intend to exploit the attractive practical advantages and opportunities that mechanochemistry offers for the development of the sustainable synthesis of complex pharmaceutical products. In particular, the research focuses on the study of a collection of the most useful tools in organic chemistry: alkylation, condensation, addition, cycloaddition and hydrogenation reactions, in both their racemic and enantioselective version. The development, optimisation and assessment of these transformations will be performed using the biologically active barbiturates as synthetic scaffolds. Moreover, through the study and determination of the key kinetic and thermodynamic parameters for the optimised mechanochemical process, and by means of computational chemistry, we will develop and validate a robust predictive model for these kinds of transformation.
This project provides a strong foundation for an innovative network that integrates organic, pharmaceutical, analytical and physical chemistry in the common pursuit of becoming greener. This research aims for a cleaner and more efficient synthesis of pharmaceuticals whilst gaining a better understanding of the physico-chemical parameters that govern mechanochemistry. We envisage that this project will open a significant number of new research opportunities in environmentally-friendly synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences organic chemistry
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- engineering and technology chemical engineering chemical process engineering
- natural sciences chemical sciences physical chemistry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
M15 6BX MANCHESTER
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.