Descrizione del progetto Virtual Physiological Human Mostra l’obiettivo del progetto Nascondi l’obiettivo del progetto The MISSION-T2D aims at developing and validating an integrated, multilevel patient-specific model for the simulation and prediction of metabolic and inflammatory processes in the onset and progress of the type 2 diabetes (T2D). The ultimate goal is to provide a diagnostic tool to estimate the risk of developing T2D and to predict its progression in response to possible therapies. In Europe, T2D is one of the most common age-related diseases and a major public health concern. Recent data show that T2D and its complications (heart, kidney, retina, diabetic foot) should be considered a systemic disease sustained by a pervasive, metabolically driven state of inflammation. Accordingly, there is an urgent need to (a) understand the complex mechanisms underpinning the onset of T2D and (b) to identify early diagnostic parameters and related inflammatory indicators, by following a personalized medicine approach. This mission will be accomplished by setting up a multi-scale model to study the systemic interactions of the involved biological mechanisms (immunological/inflammatory processes, energy intake/expenditure ratio and cell cycle rate) in response to a variety of nutritional and metabolic stimuli/stressors. The overall architecture will exploit an already established immune system simulator as well as several discrete and continuous mathematical methods for the modeling of the processes critically involved in the onset and progression of T2D. The crucial validation work will compare simulation predictions with actual biological and clinical data. MISSION-T2D aims at paving the way for translating validated multilevel immune-metabolic models into the clinical setting of T2D. Indeed, this approach will eventually generate predictive biomarkers from the integration of metabolic, nutritional, immune/inflammatory, genetic and gut microbiota profiles, as well as of clinical data, suitable to be translated into cost-effective mobile-based diagnostic tools. Campo scientifico medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineophthalmologymedical and health scienceshealth sciencespersonalized medicine Programma(i) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Argomento(i) ICT-2011.5.2 - Virtual Physiological Human Invito a presentare proposte FP7-ICT-2011-9 Vedi altri progetti per questo bando Meccanismo di finanziamento CP - Collaborative project (generic) Coordinatore CONSIGLIO NAZIONALE DELLE RICERCHE Contributo UE € 604 475,00 Indirizzo PIAZZALE ALDO MORO 7 00185 Roma Italia Mostra sulla mappa Regione Centro (IT) Lazio Roma Tipo di attività Research Organisations Contatto amministrativo Roberto Natalini (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MEDISANA SPACE TECHNOLOGIES GMBH Germania Contributo UE € 328 240,00 Indirizzo FLINGER STRASSE 11 40213 DUSSELDORF Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ulrich Schulze Althoff (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italia Contributo UE € 329 600,00 Indirizzo VIA ZAMBONI 33 40126 Bologna Mostra sulla mappa Regione Nord-Est Emilia-Romagna Bologna Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Luisa Romagnoli (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI ROMA FORO ITALICO Italia Contributo UE € 95 571,00 Indirizzo PIAZZA LAURO DE BOSIS 15 00135 ROMA Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Fabio Pigozzi (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Paesi Bassi Contributo UE € 551 964,00 Indirizzo ANNA VAN BUERENPLEIN 1 2595 DA Den Haag Mostra sulla mappa Regione West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Tipo di attività Research Organisations Contatto amministrativo Ivana Bobeldijk-Pastorova (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE € 286 921,00 Indirizzo TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Renata Schaeffer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF SHEFFIELD Regno Unito Contributo UE € 113 229,00 Indirizzo FIRTH COURT WESTERN BANK S10 2TN Sheffield Mostra sulla mappa Regione Yorkshire and the Humber South Yorkshire Sheffield Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Jo Watson (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato