Objective
In the past ten years, research in the area of drug delivery has focused on the development of vehicles that can target specific cells in the body and on the development of vehicles that specifically deliver a drug within these cells. Today, science is going one step further and the creation of vehicles that can target specific organelles within the cell is the new challenge. In this project, I aim at creating a new generation of peptide-polymer conjugates that can specifically target the Endoplasmic Reticulum (ER) and/or the Golgi Apparatus (GA) of cells. A direct application for such vehicles is the possibility to deliver antigens into dendritic cells directly in the place where they can bind to the MHC Class I complex. Efficient delivery of antigens to the MHC Class I complex triggers the activation of CD8+ cytotoxic T lymphocytes and is crucial for the creation of novel and more efficient vaccines and adjuvants. The use of polymers for targeted antigen delivery would have many advantages, not the least being an enhanced plasma half-life of the drug, improved solubility and the possibility of controlled release. The success of this will lead to the creation of a novel generation of polymeric-based immunogenics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.