Objective
"Since its discovery, DNA, the biomolecule that encodes the information necessary for the replication of life, has been the object of a vast amount of studies. The completed map of the human genome is a good example that illustrates the highly detailed information currently available about static properties of the DNA. In contrast, much less is known about the dynamic properties of DNA, i.e. about those processes occurring over ultrafast timescales shorter than a picosecond.
A particularly important dynamic process is the photoprotective mechanism. When ultraviolet (UV) radiation is absorbed by the DNA, the electronic energy acquired by the molecule is efficiently converted into vibrational energy (heat) on an ultrafast timescale (from a few tens to a few hundreds of femtoseconds) thus preventing DNA damage. This UV-induced damage to DNA has serious biological consequences, including skin cancer.
In this project we aim to establish a novel two-dimensional electronic spectroscopy technique in the ultraviolet (UV) range to study the photoprotective mechanism of the DNA.
The high temporal resolution and broad spectral tuning of the setup will enable to experimentally observe the fate of photoexcitation in DNA base monomers. These observations will unravel the details of the underlying mechanisms involved in the UV radiation dissipation, which are not only important to understand the photoprotection, but also to identify the mechanisms leading to DNA photodamage.
In addition, the results derived from this project will be crucial for further investigations in the field. For example, it will enable to investigate the misfolding mechanisms in proteins which have been connected to diseases such as Alzheimer, Parkinson and diabetes."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.