Objective
The three-dimensional organization of the genome in the nucleus is critical for many cellular processes. Hi-C is a newly developed, cutting edge method to analyze chromosome packing on a whole-genome scale using next-generation sequencing tools. Application of Hi-C to fungal and animal genomes has already revealed many new insights, providing a very high resolution picture of the nuclear arrangement of chromosomes. Given the different architecture of plant genomes, applying Hi-C to plants is very timely. Under the proposed project, Hi-C will be optimized for plant, and used to investigate the functional implications of chromosome packing in different genotypes and species. The first objective is to gain a comprehensive view of genome architecture in the model plant Arabidopsis thaliana, and to compare it to that of other organisms. The second objective is to take the advantage of high-quality whole-genome assemblies of different strains of Arabidopsis thaliana as well as of close relative, to ascertain the impact of small- and large-scale structural variation on chromosome packing. These data will be integrated with functional studies, to determine cause and effect between chromosome packing and genome features such as local transcription and chromatin modification. The third and final aim is to study how quickly chromosome packing responds to stress adaptation, as a first step towards understanding the role of chromosome packing in dynamic events.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.