Objective
Diet plays an important role on the effects of neurodevelopment and there is evidence that early nutrition can influence later neurodevelopmental outcomes. Folate and polyunsaturated fatty acids, nutrients obtained via diet, are considered of extreme importance for neurodevelopment. However, the current knowledge on this field is largely based on animal, retrospective, short-term nutritional intervention studies in humans, and the scarce randomised control studies performed in humans provide controversial results. A multi-centre well-designed project of the long-term effects of early nutrition on child’s health is needed.
Another important factor in child’s development is the effect of maternal metabolic pathologies, particularly obesity, on child’s early programming. Obese women are frequently deficient in fatty acids and folates during pregnancy, nevertheless there are only few studies on maternal BMI and its effects on nutrional status. It is not known to what extent BMI influences early programming.
The current project aims to study the short and long-term effects of early programming (maternal supplementation during pregnancy and maternal obesity) together with polymorphisms in fatty acid and folate metabolism on maternal metabolomics during pregnancy and infant’s transcriptomic and epigenomic profiles at delivery in association with child’s neurodevelopmental outcomes.
The current project would enable to establish positive dietary and body weight recommendations for women planning pregnancy and for pregnant women, which could be of broad social significance in terms of affecting health behaviours, education, work potential and mental illness in every age group. Further, the general concept that early programming might program long-term health has potentially far-reaching consequences. Additionally, the systems biology approach of integrating genetic, transcriptomic, epigenomic, and metabolomic information would provide more complete picture of living organism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine obstetrics
- medical and health sciences basic medicine pathology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
18071 GRANADA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.