Objective
Fibrosis, or scarring, is a process which complicates many diseases of the lung and other organs and for which there is no current treatment. It is also associated with many cancers. Fibrotic diseases constitute a heavy burden of morbidity and untimely deaths. There are currently no ways to detect the activity of fibrosis in human tissues in life. The aims of the project are to generate and validate, in a biological setting, a series of probes for the detection and analysis of fibrosis in vitro and in vivo. This project aims to develop ‘smart’ probes to detect fibrosis in ‘real time’. This will be achieved by the combined application of organic synthesis and ‘cutting-edge’ technology to perform optical imaging microscopy deep in diseased organs to detect the activity of a ‘tiny’ dose of a coloured compound which has been designed to specifically detect key events in the fibrotic process. The biological targets chosen are well recognised as key components of the fibrogenic pathway and are amenable for optical imaging using probe-based confocal laser endoscopy. The research pathway detailed herein will create novel active chemical “smartprobes” as markers of fibrogenesis in situ to rapidly establish early diagnosis and efficacy of much needed new therapies in scarring diseases of the lung and other organs. This technology will enable us not only to detect fibrosis, also to develop new drugs for human disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics laser physics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH8 9YL Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.