Obiettivo In the past decade, astroglia have emerged as an active and critical partner in neural circuit communication in the brain, in health and disease. However, the increasing variety of mechanisms which reportedly contribute to astroglia-neuron signal exchange is nearing a conceptual bottleneck. How these multiple and diverse mechanisms relate to the functional organisation of astroglia, whether this relationship persists or whether it adapts to neural activity remains poorly understood. Building upon substantial preliminary work and extensive collaboration, our overall objective is to establish principles that guide signal formation, integration and propagation in neural circuits interacting with astroglia. We will focus mainly on hippocampal circuitry and combine single-cell electrophysiology, multi-photon excitation imaging, time-resolved and super-resolution fluorescence microscopy, pharmaco- and optogenetic tools and extensive biophysical and neural network modelling. Firstly, we will establish whether and how glia-neuron signal exchange relates to the structure and function of individual synaptic connections represented by postsynaptic dendritic spines and presynaptic axonal boutons. Secondly, we will identify cellular mechanisms by which individual astrocytes integrate, in space and time, calcium signals arising from distinct types of local physiological input. Thirdly, we will determine physiological machinery that prompts use-dependent, meta-plastic changes in the neural circuit-astroglia exchange and in glial signal processing. Fourthly, we will establish the relationship between neural network oscillations and periodic activities of astroglial assemblies. Finally, we will undertake a computational and theoretical analysis of principles that govern the role astroglia in information handling by neural networks. We expect that the results will provide novel and conceptual insights into the basic machinery underpinning the activity of brain circuits. Campo scientifico natural scienceschemical sciencesinorganic chemistryalkaline earth metalsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processingnatural sciencesphysical sciencesopticsmicroscopynatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Invito a presentare proposte ERC-2012-ADG_20120314 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante UNIVERSITY COLLEGE LONDON Contributo UE € 2 497 690,00 Indirizzo GOWER STREET WC1E 6BT London Regno Unito Mostra sulla mappa Regione London Inner London — West Camden and City of London Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Dmitri Rusakov (Prof.) Contatto amministrativo Giles Machell (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY COLLEGE LONDON Regno Unito Contributo UE € 2 497 690,00 Indirizzo GOWER STREET WC1E 6BT London Mostra sulla mappa Regione London Inner London — West Camden and City of London Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Dmitri Rusakov (Prof.) Contatto amministrativo Giles Machell (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
