Objective
"The standard emergency treatment for myocardial infarction (MI) has so improved over the last decade that most patients survive. However, many of these patients still go on to develop heart failure over the subsequent months and years. Vascular regeneration using autologous cells, if given at an early stage in patient treatment, can promote cardiac repair following MI and reduce the adverse cardiac remodelling that leads to heart failure. However, clinical trials have clearly shown that currently available therapies provide only minor improvement in heart function and require significant refinement before they become a useful clinical treatment. Further basic research is urgently required to advance these vascular regeneration therapies to improve patient outcomes. This project builds on the recent finding that cardiac stem cell populations expressing the TGFbeta/BMP co-receptor endoglin promotes angiogenesis in the myocardial infarct region with greater efficiency than endoglin-depleted cells. As donor cells are rarely retained after stem cell transfer to the heart, this finding strongly suggests that endoglin-positive cardiac stem cells have a pro-angiogenic secretome, that is lost in the absence of endoglin. This project will take advantage of this discovery and will use mouse models of acute MI to determine the most potent combinations of pro-angiogenic protein factors that lead to cardiac vascular regeneration in vivo. By developing optimal conditions for therapeutic angiogenesis we anticipate being able to significantly reduce myocyte loss following acute MI and decrease the risk of subsequent heart failure."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine cardiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.