Objectif "The main goal of MAXPCI is the development and application of a high-potential X-ray phase-contrast imaging (XPCI) technique. XPCI has demonstrated much improved contrast compared to conventional absorption-based methods, especially when soft biological tissues (made of light elements) and high X-ray energies are considered. Due to the need of most XPCI techniques to use highly coherent radiation, however, its widespread application in normal laboratories has been until now very restricted. The edge-illumination (EI) technique, also referred to as coded-aperture (CA) technique when implemented with conventional X-ray sources, has a high potential to bridge this gap thus allowing the full exploitation of XPCI. In particular, the technique has a simple and flexible setup, and has been demonstrated to provide high phase-contrast signals also with spatially and temporally incoherent sources.More specifically, this project aims at maximizing the performance of the EI/CA technique by pushing the thresholds of the obtainable spatial resolution and sensitivity. Advances in this sense have already been demonstrated with synchrotron radiation (SR) sources: these will be optimized and then translated to conventional X-ray sources. Quantitative methods allowing the extraction of sample absorption, refraction and scattering information will also be developed, in particular single-shot ones (i.e. requiring only one input image). These will allow a reduction in the dose to the sample as well as shorter acquisition times, which are of paramount importance in particular for medical and biological imaging.The obtained advances will be exploited for various applications. In particular, the project will concentrate on three subjects that have very high potential impact: 1) breast tissue imaging (cancer detection and study of tumor invasion), 2) imaging of articular cartilage in small animals (osteoarthritis studies), 3) detection of defects in composite materials." Champ scientifique engineering and technologymaterials engineeringcompositesmedical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Appel à propositions FP7-PEOPLE-2012-CIG Voir d’autres projets de cet appel Régime de financement MC-CIG - Support for training and career development of researcher (CIG) Coordinateur UNIVERSITY COLLEGE LONDON Contribution de l’UE € 100 000,00 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Giles Machell (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
