Objetivo The REACH-project is a direct result of the FP7 StemExpand project, which aimed at the expansion and engraftment of hematopoietic and mesenchymal stem cells (MSC) for clinical use. The results of these research activities show that a novel, closed and controlled bioreactor can be developed to grow clinically relevant numbers (>400 million) of MSCs. XPand Biotechnology BV(NL) [bioreactor development, technology valorization], Aber Instruments ltd (UK)[biomass sensor] and PreSens Precision Sensing GmbH (GE) [DO, pH sensor] are three SMEs that have teamed up to develop this novel bioreactor system to a pre-commercial scale. The overall aim of the REACH project is to further develop and engineer the bioreactor (incl. valorization, testing and technical and biological validation) to a closed-system sensor-controlled bioreactor with sampling possibilities that allows for GMP-grade MSC production outside a cleanroom. The system will contain a disposable bioreactor bag with unique miniaturized disposable sensors. The DO and pH sensors use optical chemical methods capable of high frequency sampling, this ensures an enhanced stability of the expansion process. Using an expandable bioreactor the volume can be increased during cell culture, without the need for passaging of the cells. Because of this feature the system can be truly closed, without the limitations of a fixed culture substrate area. Leiden University Medical Center (NL) will validate the system and the products in a clinical setting by comparing bioreactor-expanded MSCs with GMP grade MSCs produced by established protocols in the LUMC. Successful development of this bioreactor system will be beneficial for the participating SMEs as well as the medical sector which will be able to develop cell therapies in a faster, cheaper and more efficient way. Collectively, the partners in REACH will develop an exploitation and business plan for the successful valorization of the research done in the FP7 StemExpand project. Ámbito científico engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsagricultural sciencesagricultural biotechnologybiomass Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-2 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador ACADEMISCH ZIEKENHUIS LEIDEN Aportación de la UE € 1 123 915,20 Dirección ALBINUSDREEF 2 2333 ZA Leiden Países Bajos Ver en el mapa Región West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Brigitte Wieles (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo KUROS BIOSCIENCES BV Países Bajos Aportación de la UE € 2 365 211,69 Dirección PROFESSOR BRONKHORSTLAAN 10 G 48 3723 MB Bilthoven Ver en el mapa Región West-Nederland Utrecht Utrecht Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Joost De Bruijn (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ABER INSTRUMENTS LIMITED Reino Unido Aportación de la UE € 478 359,73 Dirección SCIENCE PARK UNIT 5 CEFN LLAN SY23 3AH ABERSYSTWYTH Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Matthew Lee (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos PRESENS PRECISION SENSING GMBH Alemania Aportación de la UE € 1 044 640,40 Dirección AM BIOPARK 11 93053 Regensburg Ver en el mapa Región Bayern Oberpfalz Regensburg, Kreisfreie Stadt Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Gernot John (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
