Objective
Significance: The genetic code of the DNA provides a universal building plan for the cell’s molecular machinery. But a second code is needed to control the complexity of the human body, organizing 100 billion cells with identical genomes into 200 specialized cell types. This second code is called “epigenetic”. Defects in the epigenetic code play an important role in cancer, and they create an opportunity for new therapies. The proposed project is based on the hypothesis that dynamic and non-random changes of the epigenome contribute to cancer progression. I will quantitatively reconstruct the epigenome dynamics observed in leukemia and infer drug combinations that can reprogram the cancer epigenome to a less malignant stage.
Innovation & Approach: Technological breakthroughs have created an exciting opportunity for biomedical research: It is now possible to measure the full spectrum of epigenetic regulation operating on top of the genome and to comprehensively characterize the effect of epigenetic interventions. Capitalizing on recent advances, I will pursue an ambitious research agenda on epigenomics in biomedicine that can be summarized by the following formula: (Cancer Epigenetics + Biomedical Sequencing + Computational Modeling) • X = Biomedical Discovery.
The proposed project will cohesively combine basic biology with high-throughput technology and cutting-edge bioinformatics. The multiplying factor X denotes seamless integration – rather than addition – of all three components with equal importance and dedication, giving rise to a systems-level approach to studying epigenomics in biomedicine. The following three specific aims will be pursued:
Aim 1. Establish an epigenome research platform addressing biomedical questions (technology development)
Aim 2. Dissect the epigenome dynamics of leukemia progression (disease mechanisms & diagnostics)
Aim 3. Rational design of epigenetic combination therapies for cancer (drug effects & genomic medicine)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics epigenetics epigenomes
- medical and health sciences clinical medicine oncology leukemia
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
1090 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.