Project description High-Tech Research Intensive SMEs in FET research Show the project objective Hide the project objective We propose to engineer and validate a novel random access three-dimensional two-photon (2P) laser scanning microscope which can simultaneously image three different brain regions in the three spatial dimensions (3x3D system), where each scanned volume can exceed cubic millimeters. Our 3x3D system, which allows the simultaneous recording of neuronal activity in multiple, functionally connected distant brain volumes, is essential for understanding distributed brain computations. As each site can be scanned with sub-millisecond temporal resolution in several hundred user defined locations, the activity of single neurons in neuronal microcircuits or even neuronal compartments such as dendrites or axons will be followed. Furthermore, by combining imaging with powerful genetic methods and 3D photo-activation, we will not only record from identified circuits but also map connectivity between regions. We will validate the capability of our 3x3D system by simultaneously performing retinal, lateral geniculate nucleus, and cortical 3D imaging and photo stimulation. No currently available technology is able to achieve such multi-region 3D recordings of neuronal activity, considering not only products on the market but scientific publications as well. In the long term, the project leader SME will release a high-value added product family to the world market based on the methods and results that are realized and validated during this project. Despite steep competition from overseas laboratories, the first single region 3D 2P brain imaging was invented in Europe. Now, having similarly heavy competition this project attempts to realize the first multi-region 3D 2P brain imaging microscope. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesphysical sciencesopticslaser physics Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2013.9.2 - High-Tech Research Intensive SMEs in FET research Call for proposal FP7-ICT-2013-C See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator FEMTONICS KUTATO ES FEJLESZTO KORLATOLT FELELOSSEGU TARSASAG EU contribution € 452 550,00 Address TUZOLTO UTCA 59 1094 Budapest Hungary See on map Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patricia Varju (Dr.) Links Contact the organisation Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Switzerland EU contribution € 399 920,00 Address MAULBEERSTRASSE 66 4058 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Research Organisations Administrative Contact Dorothy Searles (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Germany EU contribution € 389 999,00 Address ROBERT ROSSLE STRASSE 10 13125 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Ioannis Legouras (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM Hungary EU contribution € 112 080,00 Address MUEGYETEM RAKPART 3 1111 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Pál Maák (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SZEGEDI TUDOMANYEGYETEM Hungary EU contribution € 300 000,00 Address DUGONICS TER 13 6720 Szeged See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Higher or Secondary Education Establishments Administrative Contact Veronika Verseghy (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PAZMANY PETER KATOLIKUS EGYETEM Hungary EU contribution € 36 450,00 Address SZENTKIRALYI UTCA 28 1088 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Erika Aliné Csereháti (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
