Objective
Many childhood brain tumour patients currently have low prognosis. The introduction and combination of new non-invasive MRI techniques to investigate tumour micro-environment may hold the key to increasing the accuracy of determining prognosis and treatment response. Diffusion weighted magnetic resonance imaging (DWI) provides information on the cellularity of tissue based on the mean apparent diffusion coefficient (ADC), and this has been used to describe tumour tissue structure. More recently the mean ADC has been shown to be the combination of different components, fast and slow, and these components may give more insight into tissue structure than ADC alone. Magnetic Resonance Spectroscopy (MRS) provides information of metabolites within the tissue, and metabolite profiles have been shown to be a strong characteristic of brain tumour type. However MRS can also be used to probe tissue micro-environment, such as temperature, and this provides another means of investigating tumours. The relative change in metabolite concentrations over different MRS echo times can be used to measure the relaxation properties (T2) and which are dependent upon molecular environment. The combination of these measurements to provide increased prognosis accuracy and measure treatment response will be investigated. The combination of MRS and DWI for diagnosis potential has been investigated, however using micro-environmental probes, diffusion components, temperature and T2 relaxation, is novel and will provide vital information gained non-invasively, which will potentially change patient treatment and outcomes. The study proposed aims to assess the tumour micro-environment thoroughly through MRS and DWI.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.