Objective
PET/MRI offers advantages in comparison with the clinically accepted PET/CT: higher soft tissue contrast, minimum radiation exposure to the patient and simultaneous data acquisition. The goal of dynamic studies is to provide information about physiological parameters. The evaluation of different parametric brain images brings new understanding of the brain and diseases. This is a new field of medical imaging called Parametric Imaging. Clinically, parametric PET and MRI images are interesting for a range of diseases such as early detection of Alzheimer’s Disease and tumour evaluation. For studying the brain and diseases parametrically, dynamic information becomes essential, because most changes of state in the brain occur at a very fast rate (milliseconds). Therefore, brain PET studies use dynamic scans, in which the activity distribution is measured over time. For obtaining the physiological parameters, it is necessary to apply kinetic models. Kinetic models require two time courses: Input Function (IF), which is the time course of the activity delivered to the tissue; and Time Activity Curves (TAC) of each voxel, which is the variation in activity over time. However, estimation of kinetic parameters may be rather difficult due to the uncertainties in TAC and in the IF. In this proposal, the main objective is to improve dynamic PET information. This objective will be achieved by improving the estimation of the IF and TAC. A novel method for estimating the IF is proposed here. The IF is estimated with an Image-Derived Input Function procedure using MRI information to correct the partial volume effect of the images. This MRI-based partial volume correction is based on priors. The TAC are going to be improved by new regularization methods, which are also based on the application of priors. The outcomes intended for this project are: evaluation of the developed methods in terms of kinetic parameters and Parametric PET/MR data are analyzed in the clinical context.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology dementia alzheimer
- engineering and technology medical engineering diagnostic imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52428 JULICH
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.