Objective "In the field of orthopedics, the contact with an implant and the new bone forming is very important to ensure a proper osteo-integration of the implant. One of the challenges is to boost bone regeneration, to limit the number of surgeries and to decrease the hospitalization time in order to reduce the costs. The nature of the implantable materials used in clinical practice is very diverse as metal, ceramics and polymers are commonly used depending on the specific application and needs.The strategies already used in clinics are based on two major routes: 1) use of osteoconductive materials or osteoconductive coatings, such as ceramic coatings, which will help to improve the connexion between the new bone forming and the implant. 2) use of osteo-inductive implants that will induce bone regeneration. The only way to achieve this osteo-induction is to deliver a bioactive protein, which is a growth factor from the bone morphogenetic family (BMP). BMP-2 and BMP-7 are two members of this family already used in practice in spine, long bone and cranio-facial surgery. However, currently, their use is limited to collagen sponges or paste, to which they are associated and poorly retained. In fact, due to this poor retention, a very high amount of BMP (typically 10 mg) is required. This leads to a high cost of the product and to possible risks of adverse side effect, notably immunogenic reaction.In this context, the current challenges are : i) to deliver these BMPs from the surface of other materials, especially polymers and metallic alloy already used in clinical practice, ii) to deliver them efficiently at much lower doses. This requires the engineering of new types of osteo-inductive surface coatings.The aim of the current project is to prove that the BMP loaded films developed in the framework of the ERC StG project BIOMIM are an innovative solution to render the surface of implants osteo-inductive." Fields of science medical and health sciencesclinical medicineodontologydental implantologymedical and health sciencesclinical medicinesurgerynatural scienceschemical sciencespolymer sciencesengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-OA-2012-PoC - European Research Council ERC Proof of Concept Call for proposal ERC-2012-PoC See other projects for this call Funding Scheme CSA-SA(POC) - Supporting action (Proof of Concept) Host institution INSTITUT POLYTECHNIQUE DE GRENOBLE EU contribution € 149 990,00 Address AVENUE FELIX VIALLET 46 38031 Grenoble Cedex 1 France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Administrative Contact Anne Meyer (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT POLYTECHNIQUE DE GRENOBLE France EU contribution € 149 990,00 Address AVENUE FELIX VIALLET 46 38031 Grenoble Cedex 1 See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Administrative Contact Anne Meyer (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data