Objective
All eukaryotic genomes contain transposable elements (TEs), sequences that duplicate themselves semi-autonomously. Although TEs can have beneficial effects, the vast majority of TE insertions are thought to be either neutral or deleterious. TEs can be harmful because they disrupt important sequences, such as regulatory elements and protein-coding sequences, attract epigenetic markers that can alter expression, and lead to duplication, deletion and rearrangement of DNA through ectopic recombination. Hosts therefore have mechanisms to repress the transposition of TEs, repression that TEs are under selection to avoid. To accomplish this, it is expected that TEs should be undergoing adaptive evolution. In this project we propose to test (i) whether TEs are undergoing adaptive evolution at the primary sequence level, (ii) whether TEs assimilate host gene fragments as a means to escape host silencing, and (iii) whether either strategy leads to an increase in TE success. We will investigate these questions in plants using examples of the two broad classes of TEs: the Sireviruses (class I LTR retrotransposon), and Mutator (class II DNA transposon). We will consider the evolution of these two families in maize and Arabidopsis thaliana, species that have very different genome sizes and numbers of TEs. To the best of our knowledge, the project represents the first attempt to elucidate the correlation between TE evolution and TE success, and only the second attempt to analyze patterns of adaptive evolution in either plant or animal TEs. Based in a highly successful research group in a worldwide recognized institute, and among a network of collaborators across Europe and USA, it will allow the applicant to obtain a strong background in population genetics theory, molecular evolution, and the implementation of state of the art statistical analysis and mathematical modeling.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences molecular biology molecular evolution
- natural sciences mathematics applied mathematics mathematical model
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BN1 9RH BRIGHTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.