Objective
Neural stem cells (NSCs) are self-renewing and multipotent progenitors generating neurons and glia in the adult vertebrate brain. The success of NSC maintenance and mobilization varies widely among species, brain territories, pathological conditions and individual environment, with important physiological impacts. On these grounds, our proposal aims to define the cellular, molecular and systems components controlling the formation of NSC-containing GZs and sustaining the dynamics of GZ reservoirs during an animal’s life, in the context of environmental challenge. We will rely on a novel and powerful model system, the dorsal telencephalon of the adult zebrafish, which harbors a large and superficially located GZ, enriched in NSCs and capable of efficient NSC recruitment. Our previous work highlighted the general relevance of this model, which harbors, like in mammals, quiescent NSCs of glial identity, and can be subject along life to pathological attrition, silencing, or amplification. This system was also instrumental in our identification of Notch signaling as a key control factor of NSC quiescence, a major parameter of GZ equilibrium. To dissect the mechanistic fundaments underlying homeostasis of this GZ, we propose here a combination of cutting edge approaches including the genetic modification and profiling of single NSCs in situ, the mathematical modeling of NSC clonal behavior in physiological and pathological states, and the development of novel optical tools to image for the first time the behavior of NSC populations and in intact, live adult vertebrate. This multidisciplinary and multi-scale approach will reveal the single-cell and population rules governing GZ dynamics, robustness and drifts in healthy and diseased conditions, and will feed these mechanisms with molecular support. More generally, it will generate a quantitative framework to probe the molecular and cellular effects of pathological and environmental challenges on NSC behavior.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology genetic engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine physiology homeostasis
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-ADG_20120314
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.