Objective
The hippocampal region is critically involved in memory formation and cannabinoids including delta9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, are known to impair hippocampus-dependent memories. Previous findings uncover the role of the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis underlying the long-term amnesic-like effects of THC. Thus, the regulation of mTOR-dependent mRNA translation after THC exposure could be an important process that elicits the distortion of hippocampal plasticity leading to memory impairment. The aim of this proposal is to characterize cell-type-specific mRNAs following THC treatment and evaluate the functional implication of such events on THC-induced memory impairment. To do so, we propose 1) to isolate and analyze actively translating mRNAs following THC exposure. This will be achieved by performing cell-type-specific isolation of ribosome-associated mRNA from CA1 hipocampal pyramidal neurons followed by standard genomic profiling technologies such as RNA-sequencing, 2) to evaluate the functional implication of some identified mRNAs on THC-induced memory impairment. This research project will allow not only to address the scientific issue in vivo at an integrated level, but also to yield important insights into the distortion of mechanisms involved in memory formation. The project should allow the fellow to learn new techniques by using powerful state-of-the-art technologies and the host institution will provide the best environment and knowledge, offering all the necessary equipment and qualified experts in the field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.