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Content archived on 2024-06-18

Non-genetic mechanisms of intrinsic antimicrobial resistance

Objective

NONANTIRES is a groundbreaking project to discover alternative ways for controlling the problem of infection treatment failures due to multidrug antimicrobial resistance. Specifically, my efforts will focus on Gram-negative bacterial opportunistic pathogens that exhibit pan-antibiotic, intrinsic resistance. My team has recently uncovered a novel resistance mechanism based on a cooperative behaviour of bacterial populations that show a heterogeneous response to antibiotics. Highly antibiotic resistant cells in low proportion within a heterogeneous population protect the majority of less resistant cells, as well as less resistant cells of other species. Protection depends on augmented production and release of bacterial molecules that diffuse to the medium and mediate increased antibiotic resistance. My team has obtained proof of principle that inhibiting the synthesis pathways for these molecules confers reduced bacterial resistance to bactericidal antibiotics. NONANTIRES's vision is to establish the molecular mechanism of protection and discover new molecules that will act as antibiotic adjuvants, ultimately providing better therapeutic solutions for combatting multidrug resistant microbes

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2013-CIG
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
EU contribution
€ 50 000,00
Address
UNIVERSITY ROAD LANYON BUILDING
BT7 1NN BELFAST
United Kingdom

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Region
Northern Ireland Northern Ireland Belfast
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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