Objective
Immune response in the intestine are tightly regulated to ensure host protective immunity in the absence of immune pathology. A permanent disturbance of this delicate balance can lead to the development of inflammatory bowel disease (IBD) comprising Crohn’s disease (CD) and ulcerative colitis (UC). The aetiology of IBD is unknown, but it is thought to involve a complex interplay among genetic, environmental, microbial and immune factors. Dysregulated effector CD4 T cell responses can be causative in IBD irrespective of the initiating events that promote them. There is compelling evidence that pathogenic CD4 T cells accumulate in the inflamed intestine and contribute to the chronicity of disease. Additionally at the onset of IBD, mucosal effector CD4 T cells acquire a pathogenic polyfunctional Th17/Th1 phenotype. However the signals and molecular events that induce and regulate the pathogenic switch in human T cells, remain unknown. Whether this phenotype can be modified in favour of a homeostatic Type 17 or regulatory T cell response also remains to be determined. Revealing the signals and mechanisms by which the differentiation programs of pathogenic CD4 T cells are induced, maintained and modulated, might open new avenues by which pathogenic and chronic CD4 T cell responses can be specifically targeted in IBD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.