TOPIC: Targeting Cytotoxic Protein Oligomers

Projektinformationen

TOPIC

ID Finanzhilfevereinbarung: 608041

Abgeschlossenes Projekt

Startdatum 1 September 2013

Enddatum 31 August 2017

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 586 111,02

EU-Beitrag € 586 111,02

Koordiniert durch

AARHUS UNIVERSITET
Denmark

Ziel

"Parkinson's disease and Huntington's disease are highly debilitating diseases for which no disease modifying treatment is available. This EID proposal, called TOPIC (Targeting Cytotoxic Protein Oligomers), will train 2 ESRs to target the oligomeric protein aggregate which accumulates in these diseases. These oligomers occur under conditions which eventually lead to the accumulation of fibrillar amyloid deposits. However, there is increasing consensus that the amyloid state is biologically inert and the cytotoxic species is the oligomeric structure. Our approach rests on the working hypothesis that the cytotoxic oligomers engage in a number of unwanted interactions with proteins and membranes. The 2 ESRs will combine proprietary technology to stabilize these oligomers with state-of-the-art mass spectrometry and biophysical techniques to identify, quantitate and rank these interactions within the context of the cellular interactome. The next goal (building directly on the EID outcome but outside its present scope) is to develop small-molecule inhibitors of these interactions as a therapeutic strategy to eliminate cell death and disease progression. This training programme offers a unique opportunity for the 2 ESRs to carry out central parts of translational research in both an academic and SME setting, spanning a multitude of different cellular, biophysical and mass spectrometric techniques of general use in the life sciences.
Our target oligomeric proteins are α-synuclein (Parkinson’s Disease) and the N-terminal part of exon 1 of huntingtin (Huntington’s Disease). By analysing two different proteins in parallel projects, we will be able to validate the robustness of our approach and potentially identify generic small molecules to target misfolded protein oligomers in general. Our approach will allow the ESRs to develop a general therapeutic strategy that targets a major class of devastating disease affecting the daily lives of millions of people throughout the world."

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › neurology › parkinson
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2013-ITN
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-ITN - Networks for Initial Training (ITN)

Koordinator

AARHUS UNIVERSITET

Kontakt Verwaltung

Anne Marie Marcussen (Mrs.)

• EU-Beitrag: € 553 875,50
• Adresse: NORDRE RINGGADE 1 ; 8000 Aarhus C ; Dänemark
• Region: Danmark › Midtjylland › Østjylland
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

Beteiligte (1)

CROSSBETA BIOSCIENCES BV

Niederlande

Kontakt Verwaltung

Martijn Gebbink (Dr.)

• EU-Beitrag: € 32 235,50
• Adresse: PADUALAAN 8 ; 3584 CH UTRECHT
• Aktivitätstyp: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Gesamtkosten: Keine Daten