Objective The overall aim of ASKLEPIOS is to unravel and increase our understanding of the mechanisms that govern pathogenesis of rabies virus (RABV) infection, in pursuit of the rational identification of novel therapeutic leads for rabies encephalitis. Several studies have been conducted over the past decades attempting to unravel the pathogenesis of this deadly disease, however with limited success. New knowledge on the mechanisms of the RABV life-cycle and interaction with the host is needed to identifying clinically applicable therapeutic leads, in search of rational intervention strategies. The project objectives are to:1. Identify molecules that inhibit RABV replication2. Identify molecules that inhibit detrimental host responses to RABV infection:3. Show whether opening the blood-brain-barrier (BBB) improves treatment efficacy:4. Validate the potential of the molecules identified under 1 and 2 to be used as post-exposure prophylaxis (PEP) when classical PEP is ineffective.In pursuit of these objectives ASKLEPIOS will perform in vitro screening of the anti-viral effect of type-I IFNs, MAP kinase inhibitors and siRNAs. Second, the therapeutic potential of inhibiting the pyroptotic pathway and inflammatory response will be investigated by using inhibitors of caspase-1, IL-1β, TNF-α IL-6 and MAP kinases. Third, the capacity of molecules to reach the brain will be first evaluated using an efficient in vitro BBB system and in vivo mouse studies.. The most efficient molecule to open the BBB will be co-administrated with the selected therapeutic molecules in the subsequent stages of the project. The results will be collected and synthesized and tested in mice to identify the most effective approach. The ability to clear infection and recover from rabies will be evaluated for each therapeutic scheme identified Fields of science natural sciencesbiological sciencesmicrobiologyvirology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.3.4-1 - Neglected infectious diseases of Central and Eastern Europe Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM EU contribution € 706 679,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam Netherlands See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Paul Huber (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all Food and Environment Research Agency United Kingdom EU contribution € 470 057,00 Address Area 1A, Nobel House, Smith Square 17 SW1P 3JR LONDON See on map Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Clare French (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VYZKUMNY USTAV VETERINARNIHO LEKARSTVI Czechia EU contribution € 482 506,00 Address HUDCOVA 296/70 621 00 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Other Administrative Contact Daniel Ruzek (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY Poland EU contribution € 428 299,00 Address Partyzantow 57 24100 Pulawy See on map Region Makroregion wschodni Lubelskie Lubelski Activity type Research Organisations Administrative Contact Jan Zmudzinski (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SZENT ISTVAN EGYETEM Participation ended Hungary EU contribution € 175 459,20 Address Pater Karoly utca 1 2100 GODOLLO See on map Activity type Higher or Secondary Education Establishments Administrative Contact Tamas Bakonyi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGRARTUDOMANYI KUTATOKOZPONT Hungary EU contribution € 239 940,00 Address BRUNSZVIK STREET 2 2462 Martonvasar See on map Region Dunántúl Közép-Dunántúl Fejér Activity type Research Organisations Administrative Contact Miklós Gyuranecz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 59 040,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Myriam Witvrouw (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTEMIS BIO-SUPPORT B.V. Netherlands EU contribution € 347 360,00 Address MOLENGRAAFFSINGEL 10 2629 JD Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Claassen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT PASTEUR France EU contribution € 21 000,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Thomas Wiest (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALLATORVOSTUDOMANYI EGYETEM Hungary EU contribution € 64 540,80 Address ISTVAN UTCA 2 1078 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Tamás Bakonyi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data