Ziel
Cells modulate progression through various stages of growth by producing regulatory factors. While a number of positive growth factors are well characterised, little is known, with the exception of interferons, of factors which exert a negative control on cell proliferation. The aim of our work has been to search for, identify, isolate and produce negative effectors of cell replication both for basic studies and for potential pharmacological application.
A 12,500 dalton N.W. protein with potent growth inhibitory activity has been identified, isolated and partially sequenced. A new interferon (IFN) with greater cell inhibitory potency than other IFN species has also been identified and is being isolated. The planned operation includes preparation of both natural and recombinant proteins, structural analysis and biological efficiency; gene cloning and engineering of high efficiency genetic constructs; receptor isolation and methods of signal transduction; biochemical and molecular mechanisms of action.
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SE1 7EH London
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