en en 109426 322605 META-GROWTH Nutrient exposure during pregnancy and childhood strongly affects growth and induces persistent metabolic programming of lifelong health. Recent data show that obesity and related disorders are induced by both fast childhood weight gain, and by formula feeding that promotes h... Nutrient exposure during pregnancy and childhood strongly affects growth and induces persistent metabolic programming of lifelong health. Recent data show that obesity and related disorders are induced by both fast childhood weight gain, and by formula feeding that promotes higher weight gain than breastfeeding. Lower protein in infant formula at levels similar to breast milk normalizes early weight gain and reduces later obesity risk as much as 2.5fold. Optimizing growth through improved substrate supply is of major importance for health prevention, but information is lacking on key mediators, effects on body composition and mechanisms of action, e.g. epigenetic modification. We use innovative approaches to identify key substrates that may mediate growth and body composition in humans, e.g. branched chain amino acids, n-6 polyunsaturated fatty acids, and others, and their epigenetic effects. We employ novel methods for high throughput targeted metabolomic and lipidomic profiling, genome-wide DNA methylation analysis, and state of the art bioinformatics. These powerful tools are applied to five well designed prospective cohort studies covering critical time periods from pregnancy to puberty. All cohorts offer precise phenotyping incl. body composition and are already or will be established. Comparative analyses across studies and populations provide added scientific value. We will identify which metabolic signals induce rapid weight gain and body fat deposition throughout childhood. We aim at identifying susceptible age periods, nutrient effects on epigenetic DNA methylation, and whether early metabolic exposures induce persistent or fluid metabolomic and epigenetic changes over time. The results should provide answers to key questions on the regulation of growth, with major benefit for scientific understanding, opportunities for future research, promotion of public health, nutrition recommendations, and development of improved food products. 2491200 2491200 2013-10-01 2018-09-30 2013-10-01 2018-09-30 60 ONG Signed Amendment 2013-07-25 00:00:00 2016-10-10 10:09:19 2016-10-10 10:09:19 106617 ERC-2012-ADG_20120314 en 1905689 999978433 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LMU

GESCHWISTER SCHOLL PLATZ 1 MUENCHEN 80539 DE N/A www.uni-muenchen.de

Institute für Informatik en HES en REC en 3442474 Berthold Koletzko

+49 89 5160 2826 +49 89 5160 7742 kEHorbNz9ScipPAfWw2/T1z/gK0aYxWbELA2dh4FGASmn4CaABxoIcZ2DioMzD5H

en 3442473 Danny Duhme

+49 89 2180 6811 +49 89 2180 6811 ZJsR4kVFOFiCyF5NY/25pI5QlWZcRYSmoMel3FMTDW4WRgP8eapns7xHEES3H/Ef

Germany DE DE DE 221940264 de,en,es,fr,it,pl 845 FP7-IDEAS-ERC FP7-IDEAS-ERC http://erc.europa.eu/ 1401 EC 837 FP7 en 12364 ERC-AG-LS7 12783 ERC-AG-LS 16702 ERC-AG 13423 ERC 845 FP7-IDEAS-ERC 1401 EC 837 FP7 de,en,es,fr,it,pl HCS de,en,es,fr,it,pl LIF de,en,es,fr,it,pl MED en 187746 The ERC META-GROWTH project started in October 2013 to study key modulators of early programming mechanisms of infant growth and body composition. A strong team of post-doc researchers, statisticians, study nurses, technicians, PhD students and support staff has been... 2016-08-23 11:29:21 de,en,es,fr,it,pl pubsum en report de,en,es,fr,it,pl sesam en ERC-AG