Objective Cardiovascular disease (CVD) mortality and morbidity is predicted to increase in Europe and worldwide in the next decades due to aging and the rise of diabetes and obesity. The link between metabolic and inflammatory disease is getting stronger, raising hopes for novel therapeutic targets to be exploited clinically. Clinical evidence generated by the Academic partners of the Athero-B-Cell Consortium demonstrates that CVD is associated with pro- and anti-atherogenic B cell responses. We aim to use existing proteomic, transcriptomic and miRNA data generated from large-scale clinical studies in previous EU-funded collaborative efforts to decipher the pathways that favor pro- and anti-atherogenic B cell functions in order to unravel a new set of therapeutic targets and refine potential vaccine strategies for CVD. The selection and validation of targets will be made possible by substantial technological advance achieved by the participating SMEs that are world leaders in the field of bioinformatics, genetic modification including humanised mouse models, and 3rd generation antisense drugs with locked nucleic-acid (LNA) design that are in Phase II human trials. Academia-led innovation includes high-resolution methodologies such as CyTOF and ImageStream to interrogate available samples from clinical trials and the ability to validate the targets of interest in accredited models of CVD. The validation in vivo and in vitro of such targets will feed into the SME pipeline accelerating the process of drug discovery. The recent clinical success of 3rd generation antisense drugs underscores the advantage of the Athero-B-Cell approach: the seamless transition from validation tools to clinical applications. Harnessing protective or abating unwanted B cell responses has the potential to improve health, innovation and competitiveness of European SME and Academia, while shedding light on the pathogenesis of CVD, the world's biggest killer. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.4.2-1 - Discovery research to reveal novel targets for cardiovascular disease treatment Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD EU contribution € 1 035 840,00 Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Conway (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all SANTARIS PHARMA A/S Denmark EU contribution € 1 020 540,00 Address Kogle alle 6 DK-2970 Horsholm See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henrik ørum (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution € 531 000,00 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact François Mach (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI GENOVA Italy EU contribution € 405 750,00 Address Via balbi 5 16126 Genova See on map Region Nord-Ovest Liguria Genova Activity type Higher or Secondary Education Establishments Administrative Contact Vincenzo Savarino (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX IV Laboratory, Lund University Sweden EU contribution € 441 000,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Jacqueline Postma (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 441 000,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Karin Krol (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 366 000,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 526 498,00 Address Gower street WC1E 6BT London See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kamila Kolasinska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BERING LIMITED United Kingdom EU contribution € 462 500,00 Address Petersham road 36 TW10 6UW Richmond See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ignat Drozdov (Dr.) Links Contact the organisation Opens in new window Total cost No data GENOWAY France EU contribution € 492 050,00 Address 31 rue saint jean de dieu technopark 2 69007 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Angélique Heckmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italy EU contribution € 170 000,00 Address Via fiorentina 151 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristiana Tozzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data