Objective
Sustained production of mature blood cell types relies on the continuous differentiation and self-renewal of a rare subset of hematopoietic stem and progenitor cells (HSPCs). HSPCs reside in bone marrow (BM) cavities within defined anatomical locations, also known as niches, where they receive and integrate regulatory cues that control their functional capacities to suit the changing physiological demands. BM spaces are extremely complex environments containing hematopoietic cells at different stages of differentiation, a heterogeneous stromal cell compartment of mesenchymal origin, an intricate vascular network and cells involved in bone metabolism. Not until recently have we started to gain some insight of the 3-d microanatomical organization, the population dynamics and the regulatory roles of these specialized subsets.
During the aging process, HSPCs experience a functional decline, which critically contributes to the age-related disorders of the hematopoietic system. As HSPCs undergo stringent regulation from specific niche components, age-related alterations of HSPC physiology are hypothesized to, at least partially, derive from microenvironmental, HSPC-extrinsic factors. Notably, the functional and structural transformations that BM stromal and vascular populations undergo as a result of aging, are poorly characrterized to date.
The fundamental aim of this proposal is to exploit novel imaging technologies and flow cytometric analysis to visualize, quantify and reconstruct in 3-dimensions the dynamics of the aging of BM microenvironment. Subsequently, we intend to describe how aged induced disorders of BM stroma ultimately control HSPC maintenance and perturb the homeostatic regulation of the hematopoietic system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
8006 ZURICH
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.