Objective
The present plan aims to build up and consolidate a research program in Pharmaceutical Nanomaterials Science based on the design, synthesis and chemical characterization of novel self-assembly polymeric nano-biomaterials and the investigation of the relationship between the nano/microstructure and the properties and new processing methods for the improvement of the biopharmaceutic performance of drugs. While the long-term goal of my research plan at the Technion is to develop versatile platforms for various therapeutic applications, the present proposal is oriented to make a substantial contribution to improve the treatment of two infectious diseases, the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and tuberculosis (TB), by developing innovative products that overcome important limitations of the products currently on the market such as poor oral bioavailability and frequent administration. The emphasis of the proposal is on the design, synthesis, processing and comprehensive characterization of the nano-biomaterials and the preliminary assessment of their biological performance in vitro and in vivo. It is a mid-to-long term of this proposal to facilitate the integration of my new research group to a multidisciplinary European network that will address challenges in HIV and TB.
The specific aims of the proposal are the development of three types of novel self-assembly nano-biomaterials and the preliminary characterization of the in vivo performance of the systems with optimal properties:
Aim 1-Development of alkoxysilane-grafted polymeric amphiphiles.
Aim 2-Development of polymeric amphiphiles conjugated with mono- and oligosaccharide residues.
Aim 3-Development of muco-adhesive polymeric micelles.
The different drug delivery systems are planned in a modular approach to enable the production of multifunctional drug nanocarriers with various features (e.g. drug encapsulation ability, muco-adhesivness, etc.).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine pneumology tuberculosis
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.