Objetivo "The objective of the present integration proposal is to establish PI’s career potential via the transfer of a state-of-the-art optical microscopy technique called localisation based single molecule detection, at the host institute. This method can enhance the spatial resolution of traditional optical microscopes by an order of magnitude, and can image samples with structures of sub-10 nm. It can be used for the examination of biological (cells, tissues, etc.) and other samples labelled with traditional fluorescent dyes or photoactive proteins. The main objective of system development is to implement polarisation sensitive multicolour imaging in 3D. Furthermore, we aim to minimise the acquisition time, which is currently the key limitation of the method. These developments will make it possible to monitor the dimer, oligomer and fibre formation of proteins. The scientific background established and the equipment procured earlier at the host institute will provide a solid foundation for the implementation of the objectives, however we aim to use the grant for the procurement of additional equipment specifically required for the project. The method proposed in the system will organically supplement the ongoing microscopy research activities at the department with single molecule detection. Wider national and international cooperation would provide the biological background required for applications. The grant would also significantly contribute to the personal career of the applicant, who has been developing similar systems. With the help of the reintegration grant the applicant would transfer the necessary knowledge and know-how to the host institute and the local research community. Based on his existing cooperation the host institute can join the “super-resolution microscopy” research network in Europe. Through his teaching and scientific activities he can contribute to the scientific excellence of Szeged in the narrower context, and that of the EU in a wider one." Ámbito científico natural sciencesphysical sciencesopticsmicroscopysuper resolution microscopynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2013-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador SZEGEDI TUDOMANYEGYETEM Aportación de la UE € 100 000,00 Dirección DUGONICS TER 13 6720 Szeged Hungría Ver en el mapa Región Alföld és Észak Dél-Alföld Csongrád Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Olga Németh (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
