Objective
Adult stem cells necessitate a transcriptional state that sustains multipotency and self-renewal for lifetime. Hematopoietic Stem Cells (HSC) are the source of all blood cells and lead both biological study and clinical utilization of stem cells – by saving thousands every year with bone-marrow transplant. However, understanding how HSC sustain stem-cell state is still limited. During my PostDoc I have generated and analyzed extensive microarrays expression datasets, identifying numerous candidate-regulators for HSCs. One of the top-hits, Hlf, also showed robust in vitro induction of HSC-like immunephenotype and functional activity. Now, focusing on Hlf aims to elucidate the molecular networks of transcriptome regulation in primitive primary hematopoietic cells. With the generation of a new reporter/conditional knockout mouse the endogenous role of Hlf will be further revealed. Taken together, this proposal continues my previous research, and going to shed new light on HSC regulation. Implications of such findings are relevant to lymphoma, and to development of novel ways to increase utilization of HSCs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
84105 Beer Sheva
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.