Cel The directed control of protein activity plays a crucial role in the regulation of growth and development of multicellular organisms. Different post-translational control mechanisms are known to influence the activity of proteins. Here, I am proposing a novel way to control the activity of proteins that function as multimeric complexes. MicroProteins, are small single-domain protein species that can influence target proteins by sequestering them into non-productive protein complexes. I have developed the concept of microProtein function and subsequently started to identify novel microProtein regulators in the model plant Arabidopsis. The aim of this proposal is to use the microProtein concept and build synthetic microProtein modules in economical import crop plants. By combining synthetic biology approaches with modern plant breeding, we intent to re-wire plant development and alter the flowering behaviour of rice. In addition, we will use a combination of artificial microProteins and microProtein-resistant transcription factors to modify the inclination angle of leaves in rice and the bioenergy model species Brachypodium distachion. Modification of the leaf angle will allow us to grow crops at higher densities, thus having the potential to increase both biomass and seed production per acreage. Finally, we aim to identify novel, evolutionary conserved microProtein-modules and unravel the mechanism of microProtein function, to study their role in plant development and adaptation. Dziedzina nauki natural sciencesbiological sciencessynthetic biologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsagricultural sciencesagriculture, forestry, and fisheriesagricultureagronomyplant breedingagricultural sciencesagricultural biotechnologybiomass Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Zaproszenie do składania wniosków ERC-2013-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca KOBENHAVNS UNIVERSITET Wkład UE € 1 189 344,80 Adres NORREGADE 10 1165 Kobenhavn Dania Zobacz na mapie Region Danmark Hovedstaden Byen København Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Stephan Wenkel (Dr.) Kontakt administracyjny Tine Mathiesen (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KOBENHAVNS UNIVERSITET Dania Wkład UE € 1 189 344,80 Adres NORREGADE 10 1165 Kobenhavn Zobacz na mapie Region Danmark Hovedstaden Byen København Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Stephan Wenkel (Dr.) Kontakt administracyjny Tine Mathiesen (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych EBERHARD KARLS UNIVERSITAET TUEBINGEN Niemcy Wkład UE € 253 975,20 Adres GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Zobacz na mapie Region Baden-Württemberg Tübingen Tübingen, Landkreis Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Elisabeth Baier (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
