Objective
The functional magnetic resonance imaging (FMRI) community is shifting its interest from localizing functions to capturing functional brain networks. To investigate the functional network architecture of the brain neuroimagers are studying the brain’s spontaneous activity using resting state FMRI (R-FMRI). Both ease-of-use and the distributed nature of the network readouts are contributing to the popularity of R-FMRI for studying clinical populations. Studies increasingly report aberrant functional connectivity within and between specific networks of interest, but with a vast variety of metrics. Such scattered diagnostic findings rarely translate into clinically useful biomarkers. By contrast, I expect that providing an integrated assessment of the brain’s functional architecture will extend our ability to stratify participants beyond diagnostic categories. Increasing our understanding of clinically relevant subtypes, we ultimately create possibilities for tailored treatment protocols. Therefore, this proposal aims to construct a functional fingerprint of the brain that is sensitive to subtle variations, inclusive in what it captures, specific when distinguishing subgroups, and well validated for clinical use. Specifically, I will construct functional fingerprints that capture the richness of functional connectivity interactions between brain regions, augmented with a behavioral profile and informed by brain structure. I will test the ability of the functional fingerprint to stratify a population into subgroups using a large ADHD-related cohort available at the host institution. Finally, I will cross-validate the functional fingerprints in two independent datasets. My proposal aims to devise integrative methods that yield results that are interpretable in a clinical setting. My R-FMRI expertise and the host institutions expertise in data-driven FMRI methodology and ADHD pathophysiology provide excellent grounds for successful completion of the objectives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.