Obiettivo The rise in use of nanotechnology has significantly increased risks of human exposure and interaction of nanoparticles with the immune system, potentially jeopardizing host responses to infection. There is a critical need to define the functional immunological consequences of chronic nanoparticle exposure. Lack of this knowledge could potentially confound efforts to prevent, diagnose, and treat infectious diseases in people whose immune system responses may have been affected by exposure to nanomaterials. The objective of the proposed studies is to define genetic and innate immune responses of zebrafish neutrophils to exposure to nano-TiO2 as well as functional consequences in host responses to disease causing pathogens. The hypothesis is that exposure to nano-TiO2 will 1) cause measurable changes in leukocyte transcriptome response and neutrophil function; and 2) increase morbidity and mortality in disease challenged zebrafish. The rationale for the proposed research is that insights into nano-TiO2 dependent changes in host immune response to pathogens will allow better assessment of risks associated with chronic exposures to metallic oxide nanoparticles.The public health relevance of the proposed research is reflected in the fact that nano products are rapidly accumulating in the environment and their potential for causing adverse health effects is growing proportionately, but the contribution of environmentally-relevant nanoparticle doses to modulation of infectious disease pathology remains unclear. The proposed research is significant because it is expected to increase our mechanistic understanding of the biological activity of nano-metallic oxides and assess their potential for chronic toxicity, and to allow us to evaluate the safety of metallic oxide nanoparticles. Integration of Dr Palic to EU scientific community network will be greatly enhanced with this opportunity to retain and expand collaborations with knowledge transfer from the U.S. to Germany. Campo scientifico medical and health scienceshealth sciencespublic healthmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepathologyengineering and technologynanotechnologynano-materials Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2013-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2013-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Contributo UE € 100 000,00 Indirizzo GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen Germania Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Danny Duhme (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato