Objective Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. The clinician is faced with the decision to either 1) intervene only on the culprit lesion acutely responsible for the initiation of cardiogenic shock, or 2) treat additional lesions considered hemodynamically significant but not acutely triggering the CS cascade as well. Current guidelines recommend percutaneous coronary intervention of all critical lesions. However, due to a lack of randomized trials, these recommendations are solely based on registry data and pathophysiological considerations. Aim of the randomized CULPRIT-SHOCK trial is therefore to compare a) immediate multivessel PCI versus b) culprit lesion only PCI in patients with AMI complicated by CS. A total of 706 CS patients will be randomized in several European countries. The primary endpoint will be 30-day all-cause mortality and/or severe renal failure requiring renal replacement therapy. CULPRIT-SHOCK will therefore determine the optimal percutaneous revascularization strategy in patients with AMI and multivessel disease complicated by CS. In addition, a comprehensive array of efficacy, safety and socio-economic parameters for the chosen population will be assessed. Multiple secondary endpoints and several substudies (microcirculation, biomarkers, angiography) will serve to further understand the presumed differential effects of the 2 treatment arms and to understand the underlying pathophysiology and prognostic markers. From these parameters a multivariable regression model and a risk score for the prediction of clinical prognosis and a cost-effectiveness model in AMI and CS will be developed. Furthermore, CULPRIT-SHOCK will obtain data on CS patients not meeting inclusion criteria by instituting a separate registry. Fields of science social sciencessociologydemographymortalitymedical and health sciencesbasic medicinephysiologypathophysiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.4.2-2 - Comparative effectiveness research of existing technologies for prevention, diagnosis and treatment of cardiovascular diseases Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITAET zu LUEBECK EU contribution € 2 100 350,00 Address RATZEBURGER ALLEE 160 23562 Lubeck Germany See on map Region Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Annette Bender (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (23) Sort alphabetically Sort by EU Contribution Expand all Collapse all STIFTUNG INSTITUT FUR HERZINFARKTFORSCHUNG LUDWIGSHAFEN Germany EU contribution € 1 060 000,00 Address BREMSERSTRASSE 79 67063 LUDWIGSHAFEN See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Ludwigshafen am Rhein, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Marco Dech (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 384 720,00 Address MEIBERGDREEF 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Edwin Groenewegen Van Wijk (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN Participation ended Austria EU contribution No data Address Montleartstrasse 37 1160 WIEN See on map Activity type Research Organisations Administrative Contact Andrea Prusse (Ms.) Links Contact the organisation Opens in new window Total cost No data VIESOJI ISTAIGA VILNIAUS UNIVERSITETO LIGONINE SANTAROS KLINIKOS Lithuania EU contribution € 41 720,00 Address SANTARISKIU G 2 LT-08661 Vilnius See on map Region Lietuva Sostinės regionas Vilniaus apskritis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Liuda Grigentiene (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 25 000,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix Pillot (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data A.C.T.I.O.N ALLIES IN CARDIOVASCULAR TRIALS INITIATIVES AND ORGANIZEDNETWORKS ASSOCIATION France EU contribution € 511 083,00 Address BOULEVARD DE L HOPITAL 47 75013 PARIS See on map Activity type Research Organisations Administrative Contact Vanessa Gallois (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERZITETNI KLINICNI CENTER LJUBLJANA Slovenia EU contribution € 72 000,00 Address ZALOSKA CESTA 002 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Higher or Secondary Education Establishments Administrative Contact Miha Zemlja (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NARODOWY INSTYTUT KARDIOLOGII STEFANA KARDYNALA WYSZYNSKIEGO - PANSTWOWY INSTYTUT BADAWCZY Poland EU contribution € 34 600,00 Address UL. ALPEJSKA 42 04 628 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Marek Banaszewski (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSELSPITAL-STIFTUNG Switzerland EU contribution € 17 046,00 Address FREIBURGSTRASSE 18 3010 BERN See on map Activity type Research Organisations Administrative Contact Stephan Windecker (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UPPSALA UNIVERSITET Participation ended Sweden EU contribution No data Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Johan Sundelin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution € 227 045,00 Address UNIVERSITY AVENUE G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Joe Galloway (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA Italy EU contribution € 10 000,00 Address VIA AMENDOLA 2 42100 Reggio Emilia See on map Region Nord-Est Emilia-Romagna Reggio nell’Emilia Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Teresa Coppola (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARCISPEDALE SANTA MARIA NUOVA AZIENDA OSPEDALIERA Participation ended Italy EU contribution No data Address VIALE UMBERTO I 50 42100 REGGIO EMILIA See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Teresa Coppola (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 125 043,00 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET LEIPZIG Germany EU contribution € 631 603,00 Address RITTERSTRASSE 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Joachim Thiery (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL WAITING TIMES CENTRE BOARD United Kingdom EU contribution € 212 380,00 Address BEARDMORE STREET CLYDEBANK G81 4HX GLASGOW See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Catherine Sinclair (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HERZZENTRUM LEIPZIG GMBH Germany EU contribution € 277 100,00 Address STRUEMPELLSTRASSE 39 04289 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Simone Bläser (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA OSPEDALIERA DELLA PROVINCIA DI LECCO Participation ended Italy EU contribution No data Address VIA DELL'EREMO 9/11 23900 LECCO See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Micol Bernardi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA SOCIO SANITARIA TERRITORIALE DI LECCO Italy EU contribution € 5 850,00 Address VIA DELLEREMO 9/11 23900 Lecco See on map Region Nord-Ovest Lombardia Lecco Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Anna Perego (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR ZIEKENHUIS ANTWERPEN Belgium EU contribution € 20 000,00 Address DRIE EIKENSTRAAT 655 2650 Edegem See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Research Organisations Administrative Contact Christiaan Vrints (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 195 645,00 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Dietz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VEREIN ZUR FORDERUNG DER FORSCHUNG AUF DEM GEBIET DER ARTERIOSKLEROSE THROMOBOSE UND VASKULAREN BIOLOGIE Austria EU contribution € 39 960,00 Address MARIAHILFER STRASSE 49/19 1060 WIEN See on map Activity type Research Organisations Administrative Contact Barbara Novak (Ms.) Links Contact the organisation Opens in new window Total cost No data INSEL GRUPPE AG Switzerland EU contribution € 8 000,00 Address FREIBURGSTRASSE 18 3010 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephan Windecker (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data