Obiettivo Atherosclerosis and its most disabling sequelae, coronary artery disease (CAD) and stroke, are leading causes of death in Europe. Until now, preventive and therapeutic interventions for these diseases aim at ameliorating the effects of established cardiovascular risk factors. More recently, results of genome-wide association (GWA) studies added to our perception of mechanisms leading to atherosclerosis. At present, over 40 CAD and several genomic risk loci have been identified, the majority through efforts led by the applicants. Some genes at these loci work through known risk factors such as lipids and, in fact, are already established or evolving treatment targets. However, this is not true for the majority of risk variants, which implies that key pathways leading to atherosclerosis are yet to be exploited for therapeutic intervention. This EU network (CVgenes@target), which brings together an equal number of SME- and academic partners, will utilize genomic variants affecting atherosclerosis risk for identification of both underlying genes and affected pathways in order to identify, characterize, and validate novel therapeutically relevant targets for prevention and treatment of CAD and stroke. In programme 1 we will investigate molecular mechanisms at the genomic loci in order to further unravel causal genes, in programme 2 we will explore in vitro and in vivo whether the pathways disturbed by causal genes are suitable for therapeutic intervention, and in programme 3 we will establish assays and initiate high throughput screens to tackle therapeutically attractive targets. Our resources including large OMICs and state-of-the-art bioinformatics platforms as well as multiple, already established in vitro and in vivo models support the feasibility of the approach. In fact, two genomic risk loci (ADAMTS7 (CAD); HDAC9 (stroke and CAD)), both identified in GWA studies under direction of the applicants, already revealed attractive targets for therapeutic intervention. Campo scientifico natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosisnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesbasic medicineneurologystroke Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.2.4.2-1 - Discovery research to reveal novel targets for cardiovascular disease treatment Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore DEUTSCHES HERZZENTRUM MUNCHEN Contributo UE € 853 354,30 Indirizzo Lazarettstrasse 36 80636 Munich Germania Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contatto amministrativo Per Larsen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (12) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF LEICESTER Regno Unito Contributo UE € 825 270,00 Indirizzo UNIVERSITY ROAD LE1 7RH Leicester Mostra sulla mappa Regione East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Marie Adams (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germania Contributo UE € 503 040,00 Indirizzo GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Martin Dichgans (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE € 354 560,00 Indirizzo WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Mostra sulla mappa Regione South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Stephen Conway (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAET zu LUEBECK Germania Contributo UE € 336 080,00 Indirizzo RATZEBURGER ALLEE 160 23562 Lubeck Mostra sulla mappa Regione Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Nadine Clausen (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAIR MEDISCH CENTRUM UTRECHT Paesi Bassi Contributo UE € 609 720,00 Indirizzo HEIDELBERGLAAN 100 3584 CX Utrecht Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Karin Krol-Simons (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOCEROS BV Partecipazione conclusa Paesi Bassi Contributo UE € 282 763,20 Indirizzo YALELAAN 46 3584 CM UTRECHT Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Remco Brandt (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato European ScreeningPort GmbH Germania Contributo UE € 60 836,50 Indirizzo Schnackenburgallee 22525 Hamburg Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Philip Gribbon (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CLINICAL GENE NETWORKS AB Svezia Contributo UE € 397 748,20 Indirizzo Karolinska Sience Park - FOGDEVRETEN 2 171 77 STOCKHOLM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Johan Björkegren (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato 4SC DISCOVERY GMBH Germania Contributo UE € 454 260,00 Indirizzo AM KLOPFERSPITZ 19A 82152 PLANEGG MARTINSRIED Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Stefan Strobl (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato GENEDATA AG Svizzera Contributo UE € 374 062,50 Indirizzo MARGARETHENSTRASSE 38 4053 BASEL Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Timo Wittenberger (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Horizon Discovery Limited Regno Unito Contributo UE € 240 179,20 Indirizzo CAMBRIDGE RESEARCH PARK CB25 9TL Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Dirk Gewert (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germania Contributo UE € 703 575,10 Indirizzo HANSASTRASSE 27C 80686 Munchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Michael Prestele (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato