Objective
World-wide, an estimated 2.2 million grafting procedures are performed each year. Bone tissue engineering has started off with the intent to replace auto- and allografts and regenerate bone through the use of cells with the aid of supporting structures and/or biomolecules. The field has shifted its focus in recent years from the attempt to generate functional implants towards the broader generation of an initial understanding of the interplay between these input parameters that are known influencing each other in various ways. The proposed research is situated in the field of tissue engineering combined with computational simulation of the timely development of the growing tissue. It aims at providing a simplified experimental setup that allows the variation of a few input parameters in a controlled way. Output parameter is the mineralized extracellular matrix (ECM) deposited by the cells that is assessed with longitudinal micro-computed tomography. Computational simulation is performed to generate an in silico model to ultimately predict the effect of influential parameters on in vitro mineralized ECM deposition. Within the project, reproducible scaffold geometries with defined structural parameters will be generated and evaluated for their in vitro influence on human mesenchymal stem cells under static and mechanically loaded conditions. The input parameters of the experiments are divided into fixed parameters that are set at the beginning of the culture and flexible parameters that can be adapted throughout the in vitro culture. Both types of parameters will serve as input parameters for computational simulations of the developing tissue. Through the understanding which parameters and perturbations influence tissue development in vitro, future translational approaches shall enable predictions on how to promote a healing response in a patient.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences mathematics pure mathematics geometry
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.